PDB entry 2w19

View 2w19 on RCSB PDB site
Description: non-covalent complex between dahp synthase and chorismate mutase from mycobacterium tuberculosis
Class: transferase/isomerase
Keywords: transferase-isomerase complex, transferase isomerase complex, aromatic amino acid biosynthesis, multi-enzyme complex, protein-protein interactions, enzyme activation, feedback regulation, shikimate pathway, complex formation, mycobacterium tuberculosis rv0948c, isomerase, transferase, drug target, enzyme catalysis
Deposited on 2008-10-16, released 2009-07-07
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-02.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.17971
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase arog
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2W19
    • Uniprot O53512 (Start-471)
    Domains in SCOPe 2.06: d2w19a_
  • Chain 'B':
    Compound: 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase arog
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2W19
    • Uniprot O53512 (Start-471)
    Domains in SCOPe 2.06: d2w19b_
  • Chain 'C':
    Compound: chorismate mutase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: chorismate mutase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w19A (A:)
mhhhhhhssgmnwtvdipidqlpslpplptdlrtrldaalakpaaqqptwpadqalamrt
vlesvppvtvpseivrlqeqlaqvakgeafllqggdcaetfmdntephirgnvrallqma
vvltygasmpvvkvariagqyakprsadidalglrsyrgdmingfapdaaarehdpsrlv
rayanasaamnlvraltssglaslhlvhdwnrefvrtspagaryealateidrglrfmsa
cgvadrnlqtaeiyashealvldyeramlrlsdgddgepqlfdlsahtvwigertrqidg
ahiafaqvianpvgvklgpnmtpelaveyverldphnkpgrltlvsrmgnhkvrdllppi
vekvqatghqviwqcdpmhgnthesstgfktrhfdrivdevqgffevhralgthpggihv
eitgenvteclggaqdisetdlagryetacdprlntqqslelaflvaemlrd

    Sequence, based on observed residues (ATOM records): (download) 
    >2w19A (A:)
wtvdipidqlpslpplptdlrtrldaalakpaaqqptwpadqalamrtvlesvppvtvps
eivrlqeqlaqvakgeafllqggdcaetfmdntephirgnvrallqmavvltygasmpvv
kvariagqyakprsadidalglrsyrgdmingfapdaaarehdpsrlvrayanasaamnl
vraltssglaslhlvhdwnrefvrtspagaryealateidrglrfmsacgvadrnlqtae
iyashealvldyeramlrlsdgepqlfdlsahtvwigertrqidgahiafaqvianpvgv
klgpnmtpelaveyverldphnkpgrltlvsrmgnhkvrdllppivekvqatghqviwqc
dpmhgntrhfdrivdevqgffevhralgthpggihveitrlntqqslelaflvaemlrd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2w19B (B:)
mhhhhhhssgmnwtvdipidqlpslpplptdlrtrldaalakpaaqqptwpadqalamrt
vlesvppvtvpseivrlqeqlaqvakgeafllqggdcaetfmdntephirgnvrallqma
vvltygasmpvvkvariagqyakprsadidalglrsyrgdmingfapdaaarehdpsrlv
rayanasaamnlvraltssglaslhlvhdwnrefvrtspagaryealateidrglrfmsa
cgvadrnlqtaeiyashealvldyeramlrlsdgddgepqlfdlsahtvwigertrqidg
ahiafaqvianpvgvklgpnmtpelaveyverldphnkpgrltlvsrmgnhkvrdllppi
vekvqatghqviwqcdpmhgnthesstgfktrhfdrivdevqgffevhralgthpggihv
eitgenvteclggaqdisetdlagryetacdprlntqqslelaflvaemlrd

    Sequence, based on observed residues (ATOM records): (download) 
    >2w19B (B:)
wtvdipilpplptdlrtrldaalakpaaqqptwpadqalamrtvlesvppvtvpseivrl
qeqlaqvakgeafllqggdcaetfmdntephirgnvrallqmavvltygasmpvvkvari
agqyakprsadidalglrsyrgdmingfapdaaarehdpsrlvrayanasaamnlvralt
ssglaslhlvhdwnrefvrtspagaryealateidrglrfmsacgvadrnlqtaeiyash
ealvldyeramlrlsdgddgepqlfdlsahtvwigertrqidgahiafaqvianpvgvkl
gpnmtpelaveyverldphnkpgrltlvsrmgnhkvrdllppivekvqatghqviwqcdp
mhgntrhfdrivdevqgffevhralgthpggihveitrlntqqslelaflvaemlrd

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.