PDB entry 2w0u

View 2w0u on RCSB PDB site
Description: crystal structure of human glycolate oxidase in complex with the inhibitor 5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylate.
Class: oxidoreductase
Keywords: flavoprotein, glycolate pathway, hydroxyacid oxidase 1, oxidoreductase, peroxisome, inhibitor
Deposited on 2008-10-10, released 2009-11-10
The last revision prior to the SCOPe 2.04 freeze date was dated 2010-01-19, with a file datestamp of 2010-01-15.
Experiment type: XRAY
Resolution: 2.84 Å
R-factor: 0.207
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hydroxyacid oxidase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2w0ua_
  • Chain 'B':
    Compound: hydroxyacid oxidase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2w0ub_
  • Chain 'C':
    Compound: hydroxyacid oxidase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2w0uc_
  • Chain 'D':
    Compound: hydroxyacid oxidase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2w0ud_
  • Heterogens: C7C, FMN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w0uA (A:)
mlprlicindyeqhaksvlpksiydyyrsgandeetladniaafsrwklyprmlrnvaet
dlstsvlgqrvsmpicvgatamqrmahvdgelatvracqslgtgmmlsswatssieevae
agpealrwlqlyiykdrevtkklvrqaekmgykaifvtvdtpylgnrlddvrnrfklppq
lrmknfetstlsfspeenfgddsglaayvakaidpsiswedikwlrrltslpivakgilr
gddareavkhglngilvsnhgarqldgvpatidvlpeiveavegkvevfldggvrkgtdv
lkalalgakavfvgrpivwglafqgekgvqdvleilkeefrlamalsgcqnvkvidktlv
rknplavski

    Sequence, based on observed residues (ATOM records): (download) 
    >2w0uA (A:)
licindyeqhaksvlpksiydyyrsgandeetladniaafsrwklyprmlrnvaetdlst
svlgqrvsmpicvgatamqrmahvdgelatvracqslgtgmmlsswatssieevaeagpe
alrwlqlyiykdrevtkklvrqaekmgykaifvtvdtpylgnrlddvrnrfklpglaayv
akaidpsiswedikwlrrltslpivakgilrgddareavkhglngilvsnhgarqldgvp
atidvlpeiveavegkvevfldggvrkgtdvlkalalgakavfvgrpivwglafqgekgv
qdvleilkeefrlamalsgcqnvkvidktlvrkn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2w0uB (B:)
mlprlicindyeqhaksvlpksiydyyrsgandeetladniaafsrwklyprmlrnvaet
dlstsvlgqrvsmpicvgatamqrmahvdgelatvracqslgtgmmlsswatssieevae
agpealrwlqlyiykdrevtkklvrqaekmgykaifvtvdtpylgnrlddvrnrfklppq
lrmknfetstlsfspeenfgddsglaayvakaidpsiswedikwlrrltslpivakgilr
gddareavkhglngilvsnhgarqldgvpatidvlpeiveavegkvevfldggvrkgtdv
lkalalgakavfvgrpivwglafqgekgvqdvleilkeefrlamalsgcqnvkvidktlv
rknplavski

    Sequence, based on observed residues (ATOM records): (download) 
    >2w0uB (B:)
licindyeqhaksvlpksiydyyrsgandeetladniaafsrwklyprmlrnvaetdlst
svlgqrvsmpicvgatamqrmahvdgelatvracqslgtgmmlsswatssieevaeagpe
alrwlqlyiykdrevtkklvrqaekmgykaifvtvdtpylgnrlddvrnrfklglaayva
kaidpsiswedikwlrrltslpivakgilrgddareavkhglngilvsnhgarqldgvpa
tidvlpeiveavegkvevfldggvrkgtdvlkalalgakavfvgrpivwglafqgekgvq
dvleilkeefrlamalsgcqnvkvidktlvrkn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2w0uC (C:)
mlprlicindyeqhaksvlpksiydyyrsgandeetladniaafsrwklyprmlrnvaet
dlstsvlgqrvsmpicvgatamqrmahvdgelatvracqslgtgmmlsswatssieevae
agpealrwlqlyiykdrevtkklvrqaekmgykaifvtvdtpylgnrlddvrnrfklppq
lrmknfetstlsfspeenfgddsglaayvakaidpsiswedikwlrrltslpivakgilr
gddareavkhglngilvsnhgarqldgvpatidvlpeiveavegkvevfldggvrkgtdv
lkalalgakavfvgrpivwglafqgekgvqdvleilkeefrlamalsgcqnvkvidktlv
rknplavski

    Sequence, based on observed residues (ATOM records): (download) 
    >2w0uC (C:)
rlicindyeqhaksvlpksiydyyrsgandeetladniaafsrwklyprmlrnvaetdls
tsvlgqrvsmpicvgatamqrmahvdgelatvracqslgtgmmlsswatssieevaeagp
ealrwlqlyiykdrevtkklvrqaekmgykaifvtvdtpylgnrlddvrnrfglaayvak
aidpsiswedikwlrrltslpivakgilrgddareavkhglngilvsnhgarqldgvpat
idvlpeiveavegkvevfldggvrkgtdvlkalalgakavfvgrpivwglafqgekgvqd
vleilkeefrlamalsgcqnvkvidktlvrkn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2w0uD (D:)
mlprlicindyeqhaksvlpksiydyyrsgandeetladniaafsrwklyprmlrnvaet
dlstsvlgqrvsmpicvgatamqrmahvdgelatvracqslgtgmmlsswatssieevae
agpealrwlqlyiykdrevtkklvrqaekmgykaifvtvdtpylgnrlddvrnrfklppq
lrmknfetstlsfspeenfgddsglaayvakaidpsiswedikwlrrltslpivakgilr
gddareavkhglngilvsnhgarqldgvpatidvlpeiveavegkvevfldggvrkgtdv
lkalalgakavfvgrpivwglafqgekgvqdvleilkeefrlamalsgcqnvkvidktlv
rknplavski

    Sequence, based on observed residues (ATOM records): (download) 
    >2w0uD (D:)
rlicindyeqhaksvlpksiydyyrsgandeetladniaafsrwklyprmlrnvaetdls
tsvlgqrvsmpicvgatamqrmahvdgelatvracqslgtgmmlsswatssieevaeagp
ealrwlqlyiykdrevtkklvrqaekmgykaifvtvdtpylgnrlddvrnrfklglaayv
akaidpsiswedikwlrrltslpivakgilrgddareavkhglngilvsnhgarqldgvp
atidvlpeiveavegkvevfldggvrkgtdvlkalalgakavfvgrpivwglafqgekgv
qdvleilkeefrlamalsgcqnvkvidktlvrkn