PDB entry 2vpp

View 2vpp on RCSB PDB site
Description: drosophila melanogaster deoxyribonucleoside kinase successfully activates gemcitabine in transduced cancer cell lines
Class: transferase
Keywords: kinase, cancer, transferase, ATP-binding, phosphoprotein, nucleoside analogs, nucleotide-binding, structure-function relationship, gemcitabine, gene therapy, DNA synthesis
Deposited on 2008-03-03, released 2009-03-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-04-14, with a file datestamp of 2009-04-10.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.209
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: deoxynucleoside kinase
    Species: Drosophila melanogaster [TaxId:7227]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vppa_
  • Chain 'B':
    Compound: deoxynucleoside kinase
    Species: Drosophila melanogaster [TaxId:7227]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vppb_
  • Heterogens: GEO, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vppA (A:)
maeaascarkgtkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnv
ngvnllelmykdpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrr
ngsleqgmyntleewykfieesihvqadliiylrtspevayerirqrarseescvplkyl
qelhelhedwlihqrrpqsckvlvldadlnlenigteyqrsessifdais

    Sequence, based on observed residues (ATOM records): (download) 
    >2vppA (A:)
tqpftvliegnigsgkttylnhfekykndiclltepvekwrnvngvnllelmykdpkkwa
mpfqsyvtltmlqshtaptnkklkimersifsarycfvenmrrngsleqgmyntleewyk
fieesihvqadliiylrtspevayerirqrarseescvplkylqelhelhedwlihqrrp
kvlvldadl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vppB (B:)
maeaascarkgtkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnv
ngvnllelmykdpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrr
ngsleqgmyntleewykfieesihvqadliiylrtspevayerirqrarseescvplkyl
qelhelhedwlihqrrpqsckvlvldadlnlenigteyqrsessifdais

    Sequence, based on observed residues (ATOM records): (download) 
    >2vppB (B:)
pftvliegnigsgkttylnhfekykndiclltepvekwrnvngvnllelmykdpkkwamp
fqsyvtltmlqshtaptnkklkimersifsarycfvenmrrngsleqgmyntleewykfi
eesihvqadliiylrtspevayerirqrseescvplkylqelhelhedwlihqrrpkvlv
ld