PDB entry 2vp6

View 2vp6 on RCSB PDB site
Description: structural studies of nucleoside analog and feedback inhibitor binding to drosophila melanogaster multisubstrate deoxyribonucleoside kinase
Class: transferase
Keywords: ATP-binding, DNA synthesis, phosphoprotein, feedback inhibition, deoxyribonucleoside kinase, salvage pathway, nucleotide-binding, dttp, kinase, complex, drosophila, transferase
Deposited on 2008-02-26, released 2008-04-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.257
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: deoxynucleoside kinase
    Species: Drosophila melanogaster [TaxId:7227]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vp6a_
  • Chain 'B':
    Compound: deoxynucleoside kinase
    Species: Drosophila melanogaster [TaxId:7227]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vp6b_
  • Chain 'C':
    Compound: deoxynucleoside kinase
    Species: Drosophila melanogaster [TaxId:7227]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vp6c_
  • Chain 'D':
    Compound: deoxynucleoside kinase
    Species: Drosophila melanogaster [TaxId:7227]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vp6d_
  • Chain 'E':
    Compound: deoxynucleoside kinase
    Species: Drosophila melanogaster [TaxId:7227]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vp6e_
  • Chain 'F':
    Compound: deoxynucleoside kinase
    Species: Drosophila melanogaster [TaxId:7227]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vp6f_
  • Chain 'G':
    Compound: deoxynucleoside kinase
    Species: Drosophila melanogaster [TaxId:7227]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vp6g_
  • Chain 'H':
    Compound: deoxynucleoside kinase
    Species: Drosophila melanogaster [TaxId:7227]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vp6h_
  • Heterogens: SO4, 5FU

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vp6A (A:)
maeaascarkgtkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnv
ngvnllelmykdpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrr
ngsleqgmyntleewykfieesihvqadliiylrtspevayerirqrarseescvplkyl
qelhelhedwlihqrrpqsckvlvldadlnlenigteyqrsessifdais

    Sequence, based on observed residues (ATOM records): (download) 
    >2vp6A (A:)
tkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnvngvnllelmyk
dpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrrngsleqgmynt
leewykfieesihvqadliiylrtspevayerirqrarseescvplkylqelhelhedwl
ihqrrpqsckvlvldad

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vp6B (B:)
maeaascarkgtkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnv
ngvnllelmykdpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrr
ngsleqgmyntleewykfieesihvqadliiylrtspevayerirqrarseescvplkyl
qelhelhedwlihqrrpqsckvlvldadlnlenigteyqrsessifdais

    Sequence, based on observed residues (ATOM records): (download) 
    >2vp6B (B:)
tkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnvngvnllelmyk
dpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrrngsleqgmynt
leewykfieesihvqadliiylrtspevayerirqrarseescvplkylqelhelhedwl
ihqckvlvldad

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2vp6C (C:)
maeaascarkgtkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnv
ngvnllelmykdpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrr
ngsleqgmyntleewykfieesihvqadliiylrtspevayerirqrarseescvplkyl
qelhelhedwlihqrrpqsckvlvldadlnlenigteyqrsessifdais

    Sequence, based on observed residues (ATOM records): (download) 
    >2vp6C (C:)
tkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnvngvnllelmyk
dpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrrngsleqgmynt
leewykfieesihvqadliiylrtspevayerirqrarseescvplkylqelhelhedwl
ihqrrpqsckvlvldad

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2vp6D (D:)
maeaascarkgtkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnv
ngvnllelmykdpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrr
ngsleqgmyntleewykfieesihvqadliiylrtspevayerirqrarseescvplkyl
qelhelhedwlihqrrpqsckvlvldadlnlenigteyqrsessifdais

    Sequence, based on observed residues (ATOM records): (download) 
    >2vp6D (D:)
tkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnvngvnllelmyk
dpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrrngsleqgmynt
leewykfieesihvqadliiylrtspevayerirqrarseescvplkylqelhelhedwl
ihckvlvldad

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2vp6E (E:)
maeaascarkgtkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnv
ngvnllelmykdpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrr
ngsleqgmyntleewykfieesihvqadliiylrtspevayerirqrarseescvplkyl
qelhelhedwlihqrrpqsckvlvldadlnlenigteyqrsessifdais

    Sequence, based on observed residues (ATOM records): (download) 
    >2vp6E (E:)
tkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnvngvnllelmyk
dpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrrngsleqgmynt
leewykfieesihvqadliiylrtspevayerirqrarseescvplkylqelhelhedwl
ihqckvlvldad

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2vp6F (F:)
maeaascarkgtkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnv
ngvnllelmykdpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrr
ngsleqgmyntleewykfieesihvqadliiylrtspevayerirqrarseescvplkyl
qelhelhedwlihqrrpqsckvlvldadlnlenigteyqrsessifdais

    Sequence, based on observed residues (ATOM records): (download) 
    >2vp6F (F:)
tkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnvngvnllelmyk
dpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrrngsleqgmynt
leewykfieesihvqadliiylrtspevayerirqrarseescvplkylqelhelhedwl
ihqckvlvldad

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2vp6G (G:)
maeaascarkgtkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnv
ngvnllelmykdpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrr
ngsleqgmyntleewykfieesihvqadliiylrtspevayerirqrarseescvplkyl
qelhelhedwlihqrrpqsckvlvldadlnlenigteyqrsessifdais

    Sequence, based on observed residues (ATOM records): (download) 
    >2vp6G (G:)
tkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnvngvnllelmyk
dpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrrngsleqgmynt
leewykfieesihvqadliiylrtspevayerirqrarseescvplkylqelhelhedwl
ihqckvlvldad

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2vp6H (H:)
maeaascarkgtkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnv
ngvnllelmykdpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrr
ngsleqgmyntleewykfieesihvqadliiylrtspevayerirqrarseescvplkyl
qelhelhedwlihqrrpqsckvlvldadlnlenigteyqrsessifdais

    Sequence, based on observed residues (ATOM records): (download) 
    >2vp6H (H:)
tkyaegtqpftvliegnigsgkttylnhfekykndiclltepvekwrnvngvnllelmyk
dpkkwampfqsyvtltmlqshtaptnkklkimersifsarycfvenmrrngsleqgmynt
leewykfieesihvqadliiylrtspevayerirqrarseescvplkylqelhelhedwl
ihqckvlvldad