PDB entry 2uuo

View 2uuo on RCSB PDB site
Description: crystal structure of murd ligase in complex with d-glu containing sulfonamide inhibitor
Class: ligase
Keywords: murd-inhibitor complex, peptidoglycan synthesis, ligase, cell wall, cell shape, cell cycle, nucleotide-binding, sulfonamide inhibitor, murd ligase, ATP-binding, cell division
Deposited on 2007-03-06, released 2008-03-25
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-03-24, with a file datestamp of 2009-03-20.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.195
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: udp-n-acetylmuramoylalanine--d-glutamate ligase
    Species: Escherichia coli [TaxId:562]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UUO (438-End)
    • Uniprot P14900 (1-437)
    Domains in SCOPe 2.02: d2uuoa1, d2uuoa2, d2uuoa3
  • Heterogens: SO4, LK3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2uuoA (A:)
madyqgknvviiglgltglscvdfflargvtprvmdtrmtppgldklpeaverhtgslnd
ewlmaadlivaspgialahpslsaaadagieivgdielfcreaqapivaitgsngkstvt
tlvgemakaagvnvgvggniglpalmllddecelyvlelssfqlettsslqavaatilnv
tedhmdrypfglqqyraaklriyenakvcvvnaddaltmpirgadercvsfgvnmgdyhl
nhqqgetwlrvkgekvlnvkemklsgqhnytnalaalaladaaglprasslkalttftgl
phrfevvlehngvrwindskatnvgsteaalnglhvdgtlhlllggdgksadfsplaryl
ngdnvrlycfgrdgaqlaalrpevaeqtetmeqamrllaprvqpgdmvllspacasldqf
knfeqrgnefarlakelgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2uuoA (A:)
adyqgknvviiglgltglscvdfflargvtprvmdtrmtppgldklpeaverhtgslnde
wlmaadlivaspgialahpslsaaadagieivgdielfcreaqapivaitgsngkstvtt
lvgemakaagvnvgvggniglpalmllddecelyvlelssfqlettsslqavaatilnvt
edhmdrypfglqqyraaklriyenakvcvvnaddaltmprcvsfgvnmgdyhlnhetwlr
vkgekvlnvkemklsgqhnytnalaalaladaaglprasslkalttftglphrfevvleh
ngvrwindskatnvgsteaalnglhvdgtlhlllggdgksadfsplarylngdnvrlycf
grdgaqlaalrpevaeqtetmeqamrllaprvqpgdmvllspacasldqfknfeqrgnef
arlakelgsh