PDB entry 2tun

View 2tun on RCSB PDB site
Description: conformational changes in the (ala-84-val) mutant of tumor necrosis factor
Class: lymphokine
Keywords: lymphokine
Deposited on 1993-10-06, released 1994-01-31
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.198
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tumor necrosis factor-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01375 (Start-156)
      • conflict (83)
      • conflict (142)
    Domains in SCOPe 2.02: d2tuna_
  • Chain 'B':
    Compound: tumor necrosis factor-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01375 (Start-156)
      • conflict (83)
      • conflict (142)
    Domains in SCOPe 2.02: d2tunb_
  • Chain 'C':
    Compound: tumor necrosis factor-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01375 (Start-156)
      • conflict (83)
      • conflict (142)
    Domains in SCOPe 2.02: d2tunc_
  • Chain 'D':
    Compound: tumor necrosis factor-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01375 (Start-156)
      • conflict (83)
      • conflict (142)
    Domains in SCOPe 2.02: d2tund_
  • Chain 'E':
    Compound: tumor necrosis factor-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01375 (Start-156)
      • conflict (83)
      • conflict (142)
    Domains in SCOPe 2.02: d2tune_
  • Chain 'F':
    Compound: tumor necrosis factor-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01375 (Start-156)
      • conflict (83)
      • conflict (142)
    Domains in SCOPe 2.02: d2tunf_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2tunA (A:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyllfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >2tunA (A:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiylggvfql
ekgdrlsaeinrpdyllfaesgqvyfgiial

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2tunB (B:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyllfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >2tunB (B:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiylggvfql
ekgdrlsaeinrpdyllfaesgqvyfgiial

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2tunC (C:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyllfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >2tunC (C:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiylggvfql
ekgdrlsaeinrpdyllfaesgqvyfgiial

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2tunD (D:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyllfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >2tunD (D:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiylggvfql
ekgdrlsaeinrpdyllfaesgqvyfgiial

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2tunE (E:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyllfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >2tunE (E:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiylggvfql
ekgdrlsaeinrpdyllfaesgqvyfgiial

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2tunF (F:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyllfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >2tunF (F:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisrivvsyqtkvnllsaikspcqretpegaeakpwyepiylggvfql
ekgdrlsaeinrpdyllfaesgqvyfgiial