PDB entry 2req

View 2req on RCSB PDB site
Description: methylmalonyl-coa mutase, non-productive coa complex, in open conformation representing substrate-free state
Class: isomerase
Keywords: isomerase, mutase, intramolecular transferase
Deposited on 1997-09-22, released 1998-01-28
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-10-24, with a file datestamp of 2012-10-19.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.259
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: methylmalonyl-coa mutase
    Species: Propionibacterium freudenreichii [TaxId:1752]
    Gene: MUTA, MUTB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2reqa1, d2reqa2
  • Chain 'B':
    Compound: methylmalonyl-coa mutase
    Species: Propionibacterium freudenreichii [TaxId:1752]
    Gene: MUTA, MUTB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11652
      • see remark 999 (201)
      • see remark 999 (328-329)
    Domains in SCOPe 2.04: d2reqb1, d2reqb2
  • Chain 'C':
    Compound: methylmalonyl-coa mutase
    Species: Propionibacterium freudenreichii [TaxId:1752]
    Gene: MUTA, MUTB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2reqc1, d2reqc2
  • Chain 'D':
    Compound: methylmalonyl-coa mutase
    Species: Propionibacterium freudenreichii [TaxId:1752]
    Gene: MUTA, MUTB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11652
      • see remark 999 (201)
      • see remark 999 (328-329)
    Domains in SCOPe 2.04: d2reqd1, d2reqd2
  • Heterogens: COA, B12, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2reqA (A:)
stlprfdsvdlgnapvpadaarrfeelaakagtgeawetaeqipvgtlfnedvykdmdwl
dtyagippfvhgpyatmyafrpwtirqyagfstakesnafyrrnlaagqkglsvafdlpt
hrgydsdnprvagdvgmagvaidsiydmrelfagipldqmsvsmtmngavlpilalyvvt
aeeqgvkpeqlagtiqndilkefmvrntyiyppqpsmriiseifaytsanmpkwnsisis
gyhmqeagatadiemaytladgvdyiragesvglnvdqfaprlsffwgigmnffmevakl
raarmlwaklvhqfgpknpksmslrthsqtsgwsltaqdvynnvvrtcieamaatqghtq
slhtnsldeaialptdfsariarntqlflqqesgttrvidpwsgsayveeltwdlarkaw
ghiqevekvggmakaiekgipkmrieeaaartqaridsgrqpligvnkyrleheppldvl
kvdnstvlaeqkaklvklraerdpekvkaaldkitwaagnpddkdpdrnllklcidagra
matvgemsdalekvfgrytaqirtisgvyskevkntpeveearelveefeqaegrrpril
lakmgqdghdrgqkviatayadlgfdvdvgplfqtpeetarqaveadvhvvgvsslaggh
ltlvpalrkeldklgrpdilitvggvipeqdfdelrkdgaveiytpgtvipesaislvkk
lraslda

    Sequence, based on observed residues (ATOM records): (download) 
    >2reqA (A:)
lprfdsvdlgnapvpadaarrfeelaakagtgeawetaeqipvgtlfnedvykdmdwldt
yagippfvhgpyatmyafrpwtirqyagfstakesnafyrrnlaagqkglsvafdlpthr
gydsdnprvagdvgmagvaidsiydmrelfagipldqmsvsmtmngavlpilalyvvtae
eqgvkpeqlagtiqndilkefmvrntyiyppqpsmriiseifaytsanmpkwnsisisgy
hmqeagatadiemaytladgvdyiragesvglnvdqfaprlsffwgigmnffmevaklra
armlwaklvhqfgpknpksmslrthsqtsgwsltaqdvynnvvrtcieamaatqghtqsl
htnsldeaialptdfsariarntqlflqqesgttrvidpwsgsayveeltwdlarkawgh
iqevekvggmakaiekgipkmrieeaaartqaridsgrqpligvnkyrleheppldvlkv
dnstvlaeqkaklvklraerdpekvkaaldkitwaagnpddkdpdrnllklcidagrama
tvgemsdalekvfgrytaqirtisgvyskevkntpeveearelveefeqaegrrprilla
kmgqdghdrgqkviatayadlgfdvdvgplfqtpeetarqaveadvhvvgvsslagghlt
lvpalrkeldklgrpdilitvggvipeqdfdelrkdgaveiytpgtvipesaislvkklr
aslda

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2reqB (B:)
sstdqgtnpadtddltpttlslagdfpkateeqwerevekvlnrgrppekqltfaeclkr
ltvhtvdgidivpmyrpkdapkklgypgvapftrgttvrngdmdawdvralhedpdekft
rkaileglergvtslllrvdpdaiapehldevlsdvllemtkvevfsrydqgaaaealvs
vyersdkpakdlalnlgldpigfaalqgtepdltvlgdwvrrlakfspdsravtidaniy
hnagagdvaelawalatgaeyvralveqgftateafdtinfrvtathdqfltiarlralr
eawarigevfgvdedkrgarqnaitswreltredpyvnilrgsiatfsasvggaesittl
pftqalglpeddfplriarntgivlaeevnigrvndpaggsyyvesltrsladaawkefq
eveklggmskavmtehvtkvldacnaerakrlanrkqpitavsefpmigarsietkpfpa
aparkglawhrdsevfeqlmdrstsvserpkvflaclgtrrdfggregfsspvwhiagid
tpqveggttaeiveafkksgaqvadlcssakvyaqqglevakalkaagakalylsgafke
fgddaaeaeklidgrlfmgmdvvdtlsstldilgvak

    Sequence, based on observed residues (ATOM records): (download) 
    >2reqB (B:)
tpttlslagdfpkateeqwerevekvlnrgrppekqltfaeclkrltvhtvdgidivpmy
rpkdapkklgypgvapftrgttvrngdmdawdvralhedpdekftrkaileglergvtsl
llrvdpdaiapehldevlsdvllemtkvevfsrydqgaaaealvsvyersdkpakdlaln
lgldpigfaalqgtepdltvlgdwvrrlakfspdsravtidaniyhnagagdvaelawal
atgaeyvralveqgftateafdtinfrvtathdqfltiarlralreawarigevfgvded
krgarqnaitswreltredpyvnilrgsiatfsasvggaesittlpftqalglpeddfpl
riarntgivlaeevnigrvndpaggsyyvesltrsladaawkefqeveklggmskavmte
hvtkvldacnaerakrlanrkqpitavsefpmigarsietkpfpaaparkglawhrdsev
feqlmdrstsvserpkvflaclgtrrdfggregfsspvwhiagidtpqvettaeiveafk
ksgaqvadlcssakvyaqqglevakalkaagakalylsgafkefgddaaeaeklidgrlf
mgmdvvdtlsstldilgva

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2reqC (C:)
stlprfdsvdlgnapvpadaarrfeelaakagtgeawetaeqipvgtlfnedvykdmdwl
dtyagippfvhgpyatmyafrpwtirqyagfstakesnafyrrnlaagqkglsvafdlpt
hrgydsdnprvagdvgmagvaidsiydmrelfagipldqmsvsmtmngavlpilalyvvt
aeeqgvkpeqlagtiqndilkefmvrntyiyppqpsmriiseifaytsanmpkwnsisis
gyhmqeagatadiemaytladgvdyiragesvglnvdqfaprlsffwgigmnffmevakl
raarmlwaklvhqfgpknpksmslrthsqtsgwsltaqdvynnvvrtcieamaatqghtq
slhtnsldeaialptdfsariarntqlflqqesgttrvidpwsgsayveeltwdlarkaw
ghiqevekvggmakaiekgipkmrieeaaartqaridsgrqpligvnkyrleheppldvl
kvdnstvlaeqkaklvklraerdpekvkaaldkitwaagnpddkdpdrnllklcidagra
matvgemsdalekvfgrytaqirtisgvyskevkntpeveearelveefeqaegrrpril
lakmgqdghdrgqkviatayadlgfdvdvgplfqtpeetarqaveadvhvvgvsslaggh
ltlvpalrkeldklgrpdilitvggvipeqdfdelrkdgaveiytpgtvipesaislvkk
lraslda

    Sequence, based on observed residues (ATOM records): (download) 
    >2reqC (C:)
lprfdsvdlgnapvpadaarrfeelaakagtgeawetaeqipvgtlfnedvykdmdwldt
yagippfvhgpyatmyafrpwtirqyagfstakesnafyrrnlaagqkglsvafdlpthr
gydsdnprvagdvgmagvaidsiydmrelfagipldqmsvsmtmngavlpilalyvvtae
eqgvkpeqlagtiqndilkefmvrntyiyppqpsmriiseifaytsanmpkwnsisisgy
hmqeagatadiemaytladgvdyiragesvglnvdqfaprlsffwgigmnffmevaklra
armlwaklvhqfgpknpksmslrthsqtsgwsltaqdvynnvvrtcieamaatqghtqsl
htnsldeaialptdfsariarntqlflqqesgttrvidpwsgsayveeltwdlarkawgh
iqevekvggmakaiekgipkmrieeaaartqaridsgrqpligvnkyrleheppldvlkv
dnstvlaeqkaklvklraerdpekvkaaldkitwaagnpddkdpdrnllklcidagrama
tvgemsdalekvfgrytaqirtisgvyskevkntpeveearelveefeqaegrrprilla
kmgqdghdrgqkviatayadlgfdvdvgplfqtpeetarqaveadvhvvgvsslagghlt
lvpalrkeldklgrpdilitvggvipeqdfdelrkdgaveiytpgtvipesaislvkklr
aslda

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2reqD (D:)
sstdqgtnpadtddltpttlslagdfpkateeqwerevekvlnrgrppekqltfaeclkr
ltvhtvdgidivpmyrpkdapkklgypgvapftrgttvrngdmdawdvralhedpdekft
rkaileglergvtslllrvdpdaiapehldevlsdvllemtkvevfsrydqgaaaealvs
vyersdkpakdlalnlgldpigfaalqgtepdltvlgdwvrrlakfspdsravtidaniy
hnagagdvaelawalatgaeyvralveqgftateafdtinfrvtathdqfltiarlralr
eawarigevfgvdedkrgarqnaitswreltredpyvnilrgsiatfsasvggaesittl
pftqalglpeddfplriarntgivlaeevnigrvndpaggsyyvesltrsladaawkefq
eveklggmskavmtehvtkvldacnaerakrlanrkqpitavsefpmigarsietkpfpa
aparkglawhrdsevfeqlmdrstsvserpkvflaclgtrrdfggregfsspvwhiagid
tpqveggttaeiveafkksgaqvadlcssakvyaqqglevakalkaagakalylsgafke
fgddaaeaeklidgrlfmgmdvvdtlsstldilgvak

    Sequence, based on observed residues (ATOM records): (download) 
    >2reqD (D:)
tpttlslagdfpkateeqwerevekvlnrgrppekqltfaeclkrltvhtvdgidivpmy
rpkdapkklgypgvapftrgttvrngdmdawdvralhedpdekftrkaileglergvtsl
llrvdpdaiapehldevlsdvllemtkvevfsrydqgaaaealvsvyersdkpakdlaln
lgldpigfaalqgtepdltvlgdwvrrlakfspdsravtidaniyhnagagdvaelawal
atgaeyvralveqgftateafdtinfrvtathdqfltiarlralreawarigevfgvded
krgarqnaitswreltredpyvnilrgsiatfsasvggaesittlpftqalglpeddfpl
riarntgivlaeevnigrvndpaggsyyvesltrsladaawkefqeveklggmskavmte
hvtkvldacnaerakrlanrkqpitavsefpmigarsietkpfpaaparkglawhrdsev
feqlmdrstsvserpkvflaclgtrrdfggregfsspvwhiagidtpqvettaeiveafk
ksgaqvadlcssakvyaqqglevakalkaagakalylsgafkefgddaaeaeklidgrlf
mgmdvvdtlsstldilgva