PDB entry 2rax

View 2rax on RCSB PDB site
Description: Crystal structure of Borealin (20-78) bound to Survivin (1-120)
Class: cell cycle
Keywords: Cell cycle, DasraB, chromosomal passender complex, IAP, BIR, Apoptosis, Cell division, Centromere, Chromosomal protein, Metal-binding, Mitosis, Nucleus, Phosphorylation, Protease inhibitor, Thiol protease inhibitor
Deposited on 2007-09-17, released 2007-10-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: 0.239
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Baculoviral IAP repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC5, API4, IAP4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2raxa1
  • Chain 'B':
    Compound: Borealin
    Species: Homo sapiens [TaxId:9606]
    Gene: CDCA8, PESCRG3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q53HL2 (1-End)
      • expression tag (0)
  • Chain 'E':
    Compound: Baculoviral IAP repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC5, API4, IAP4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2raxe1
  • Chain 'F':
    Compound: Borealin
    Species: Homo sapiens [TaxId:9606]
    Gene: CDCA8, PESCRG3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q53HL2 (1-End)
      • expression tag (0)
  • Chain 'X':
    Compound: Baculoviral IAP repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC5, API4, IAP4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2raxx1
  • Chain 'Y':
    Compound: Borealin
    Species: Homo sapiens [TaxId:9606]
    Gene: CDCA8, PESCRG3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q53HL2 (1-End)
      • expression tag (0)
  • Heterogens: ZN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2raxA (A:)
gshmgaptlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqc
ffcfkelegwepdddpieehkkhssgcaflsvkkqfeeltlgeflkldreraknkiaket
nnk

    Sequence, based on observed residues (ATOM records): (download) 
    >2raxA (A:)
tlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcffcfkel
egwepdddpieehkkhssgcaflsvkkqfeeltlgeflkldreraknkiaketnn

  • Chain 'B':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2raxE (E:)
gshmgaptlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqc
ffcfkelegwepdddpieehkkhssgcaflsvkkqfeeltlgeflkldreraknkiaket
nnk

    Sequence, based on observed residues (ATOM records): (download) 
    >2raxE (E:)
tlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcffcfkel
egwepdddpieehkkhssgcaflsvkkqfeeltlgeflkldreraknkiaketnn

  • Chain 'F':
    No sequence available.

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >2raxX (X:)
gshmgaptlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqc
ffcfkelegwepdddpieehkkhssgcaflsvkkqfeeltlgeflkldreraknkiaket
nnk

    Sequence, based on observed residues (ATOM records): (download) 
    >2raxX (X:)
tlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcffcfkel
egwepdddpieehkkhssgcaflsvkkqfeeltlgeflkldreraknkiaketnn

  • Chain 'Y':
    No sequence available.