PDB entry 2r8j

View 2r8j on RCSB PDB site
Description: Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA
Class: replication, transferase/DNA
Keywords: protein-cisplatin-DNA-dNTP complex, REPLICATION, TRANSFERASE-DNA COMPLEX
Deposited on 2007-09-11, released 2007-12-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.208
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA Polymerase ETA
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: RAD30, DBH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04049 (23-End)
      • expression tag (21-22)
    Domains in SCOPe 2.08: d2r8ja1, d2r8ja2, d2r8ja3
  • Chain 'B':
    Compound: DNA Polymerase ETA
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: RAD30, DBH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2r8jb1, d2r8jb2
  • Chain 'P':
    Compound: DNA (5'-d(*dgp*dtp*dgp*dgp*dap*dtp*dgp*dap*dg)-3')
  • Chain 'Q':
    Compound: DNA (5'-d(*dgp*dtp*dgp*dgp*dap*dtp*dgp*dap*dg)-3')
  • Chain 'T':
    Compound: DNA (5'-d(p*dgp*dgp*dcp*dtp*dcp*dap*dtp*dcp*dcp*dap*dc)-3')
  • Chain 'U':
    Compound: DNA (5'-d(p*dgp*dgp*dcp*dtp*dcp*dap*dtp*dcp*dcp*dap*dc)-3')
  • Heterogens: CPT, CA, DCP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2r8jA (A:)
maswshpqfekgastslykkagrmskftwkeliqlgspskayesslaciahidmnaffaq
veqmrcglskedpvvcvqwnsiiavsyaarkygisrmdtiqealkkcsnlipihtavfkk
gedfwqyhdgcgswvqdpakqisvedhkvslepyrresrkalkifksacdlverasidev
fldlgricfnmlmfdneyeltgdlklkdalsnireafiggnydinshlplipekikslkf
egdvfnpegrdlitdwddvilalgsqvckgirdsikdilgyttscglsstknvcklasny
kkpdaqtivkndclldfldcgkfeitsfwtlggvlgkelidvldlphensikhiretwpd
nagqlkefldakvkqsdydrstsnidplktadlaeklfklsrgryglplssrpvvksmms
nknlrgkscnsivdciswlevfcaeltsriqdleqeynkiviprtvsislktksyevyrk
sgpvaykginfqshellkvgikfvtdldikgknksyypltklsmtitnfdiidlqktvvd
mfgnqvhtfkssag

    Sequence, based on observed residues (ATOM records): (download) 
    >2r8jA (A:)
grmskftwkeliqlgspskayesslaciahidmnaffaqveqmrcglskedpvvcvqwns
iiavsyaarkygisrmdtiqealkkcsnlipihtavfkkgedfwqyhdgcgswvqdpakq
isvedhkvslepyrresrkalkifksacdlverasidevfldlgricfnmlmfdneyelt
gdlklkdalsnireafiggnydinshlplipekikslkfegdvfnpegrdlitdwddvil
algsqvckgirdsikdilgyttscglsstknvcklasnykkpdaqtivkndclldfldcg
kfeitsfwtlggvlgkelidvldlphensikhiretwpdnagqlkefldakvkqsdydrs
tsnidplktadlaeklfklsrgryglplssrpvvksmmsnknlrgkscnsivdciswlev
fcaeltsriqdleqeynkiviprtvsislktksyevyrksgpvaykginfqshellkvgi
kfvtdldikgknksyypltklsmtitnfdii

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2r8jB (B:)
maswshpqfekgastslykkagrmskftwkeliqlgspskayesslaciahidmnaffaq
veqmrcglskedpvvcvqwnsiiavsyaarkygisrmdtiqealkkcsnlipihtavfkk
gedfwqyhdgcgswvqdpakqisvedhkvslepyrresrkalkifksacdlverasidev
fldlgricfnmlmfdneyeltgdlklkdalsnireafiggnydinshlplipekikslkf
egdvfnpegrdlitdwddvilalgsqvckgirdsikdilgyttscglsstknvcklasny
kkpdaqtivkndclldfldcgkfeitsfwtlggvlgkelidvldlphensikhiretwpd
nagqlkefldakvkqsdydrstsnidplktadlaeklfklsrgryglplssrpvvksmms
nknlrgkscnsivdciswlevfcaeltsriqdleqeynkiviprtvsislktksyevyrk
sgpvaykginfqshellkvgikfvtdldikgknksyypltklsmtitnfdiidlqktvvd
mfgnqvhtfkssag

    Sequence, based on observed residues (ATOM records): (download) 
    >2r8jB (B:)
mskftwkeliqlgspskayesslaciahidmnaffaqveqmrcglskedpvvcvqwnsii
avsyaarkygisrmdtiqealkkcsnlipihtavfkkgedfwqyhdgcgswvqdpakqis
vedhkvslepyrresrkalkifksacdlverasidevfldlgricfnmlmfdneyeltgd
lklkdalsnireafiggnydinshlplipekikslkfegdvfnpegrdlitdwddvilal
gsqvckgirdsikdilgyttscglsstknvcklasnykkpdaqtivkndclldfldcgkf
eitsfwtlggvlgkelidvldlphensikhiretwpdnagqlkefldakvkqsdydrsts
nidplktadlaeklfklsrgryglplssrpvvksmmsnknlrgkscnsivdciswlevfc
aeltsriqdleqeynkiviprtvsislktksyevyrksgpvaykginfqshellkvgikf
vtdldikgknksyypltklsmtitnfdii

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.

  • Chain 'T':
    No sequence available.

  • Chain 'U':
    No sequence available.