PDB entry 2qwr

View 2qwr on RCSB PDB site
Description: Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the AMPPNP intact form
Class: chaperone
Keywords: chaperone-cochaperone complex, ATP-binding, Cytoplasm, Nucleotide-binding, Nucleus, Phosphorylation, Stress response, Hydrolase, Protein phosphatase, SH3-binding
Deposited on 2007-08-10, released 2007-12-18
The last revision prior to the SCOP 1.75 freeze date was dated 2007-12-18, with a file datestamp of 2007-12-14.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: 0.233
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock cognate 71 kDa protein
    Species: BOS TAURUS
    Gene: HSPA8, HSC70
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19120
      • engineered (170)
    Domains in SCOP 1.75: d2qwra1, d2qwra2
  • Chain 'B':
    Compound: Putative tyrosine-protein phosphatase auxilin
    Species: BOS TAURUS
    Gene: DNAJC6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q27974 (0-91)
      • engineered (63)
  • Heterogens: ANP, ACY, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qwrA (A:)
mskgpavgidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqva
mnptntvfdakrligrrfddavvqsdmkhwpfmvvndagrpkvqveykgetksfypeevs
smvltkmkeiaeaylgktvtnavvtvpayfndsqrqatkdagtiaglnvlciineptaaa
iaygldkkvgaernvlifdlgggtfdvsiltiedgifevkstagdthlggedfdnrmvnh
fiaefkrkhkkdisenkravrrlrtacerakrtlssstqasieidslyegidfytsitra
rfeelnadlfrgtldpvekalrdakldksqihdivlvggstripkiqkllqdffngkeln
ksinpdeavaygaavqaailsgdksenvqdllll

    Sequence, based on observed residues (ATOM records): (download) 
    >2qwrA (A:)
gpavgidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqvamnp
tntvfdakrligrrfddavvqsdmkhwpfmvvndagrpkvqveykgetksfypeevssmv
ltkmkeiaeaylgktvtnavvtvpayfndsqrqatkdagtiaglnvlciineptaaaiay
gldkkvgaernvlifdlgggtfdvsiltiedgifevkstagdthlggedfdnrmvnhfia
efkrkhkkdisenkravrrlrtacerakrtlssstqasieidslyegidfytsitrarfe
elnadlfrgtldpvekalrdakldksqihdivlvggstripkiqkllqdffngkelnksi
npdeavaygaavqaailsgdkse

  • Chain 'B':
    No sequence available.