PDB entry 2qis

View 2qis on RCSB PDB site
Description: Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate
Class: transferase
Keywords: trans-prenyltransferase, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2007-07-05, released 2007-07-24
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.179
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Farnesyl pyrophosphate synthetase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14324
      • engineered (221)
    Domains in SCOPe 2.04: d2qisa_
  • Heterogens: MG, RIS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qisA (A:)
gsshhhhhhssgrenlyfqghmngdqnsdvyaqekqdfvqhfsqivrvltedemghpeig
daiarlkevleynaiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaff
lvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnliel
flqssyqteigqtldlltapqgnvdlvrftekryksivkyksafysfylpiaaamymagi
dgekehanakkillemgeffqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqrat
peqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplppa
vflglarkiykrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >2qisA (A:)
dvyaqekqdfvqhfsqivrvltedehpeigdaiarlkevleynaiggkynrgltvvvafr
elveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldai
ndanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrft
ekryksivkyksafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlf
gdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeld
lpavflqyeedsyshimalieqyaaplppavflglarkiy