PDB entry 2pzg

View 2pzg on RCSB PDB site
Description: Minimal human CFTR first nucleotide binding domain as a monomer
Class: Hydrolase
Keywords: NBD, ABC transporter, CFTR, Hydrolase
Deposited on 2007-05-18, released 2007-10-09
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.204
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR, ABCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (Start-30)
      • variant (64)
    • Uniprot P13569 (31-240)
    Domains in SCOPe 2.05: d2pzga_
  • Chain 'B':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR, ABCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (Start-30)
      • variant (64)
    • Uniprot P13569 (31-End)
    Domains in SCOPe 2.05: d2pzgb_
  • Heterogens: MG, ATP, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2pzgA (A:)
slqkqeyktleynltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagkt
sllmmimgelepsegkikhsgrisfcsqfswimpgtikeniifgvsydeyryrsvikacq
leediskfaekdnivlgeggitlsggqrarislaravykdadlylldspfgyldvlteke
ifescvcklmanktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklm
g

    Sequence, based on observed residues (ATOM records): (download) 
    >2pzgA (A:)
tevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgelepsegk
ikhsgrisfcsqfswimpgtikeniifgvsydeyryrsvikacqleediskfaekdnivl
geggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktri
lvtskmehlkkadkililhegssyfygtfselqnpdfssklmg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2pzgB (B:)
slqkqeyktleynltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagkt
sllmmimgelepsegkikhsgrisfcsqfswimpgtikeniifgvsydeyryrsvikacq
leediskfaekdnivlgeggitlsggqrarislaravykdadlylldspfgyldvlteke
ifescvcklmanktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklm
g

    Sequence, based on observed residues (ATOM records): (download) 
    >2pzgB (B:)
ltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgeleps
egkikhsgrisfcsqfswimpgtikeniifgvsydeyryrsvikacqleediskfaekdn
ivlgitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktri
lvtskmehlkkadkililhegssyfygtfselqnl