PDB entry 2p6x

View 2p6x on RCSB PDB site
Description: Crystal structure of human tyrosine phosphatase PTPN22
Class: hydrolase
Keywords: Tyrosine phosphatase, Lymphoid phosphatase, PEP, LYP, Structural Genomics, Structural Genomics Consortium, SGC, HYDROLASE
Deposited on 2007-03-19, released 2007-04-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 22
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN22, PTPN8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y2R2 (0-301)
      • cloning artifact (302)
    Domains in SCOPe 2.07: d2p6xa1, d2p6xa2
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 22
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN22, PTPN8
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2p6xb_
  • Heterogens: EDO, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2p6xA (A:)
mdqreilqkfldeaqskkitkeefaneflklkrqstkykadktypttvaekpknikknry
kdilpydysrvelslitsdedssyinanfikgvygpkayiatqgplsttlldfwrmiwey
svliivmacmeyemgkkkcerywaepgemqlefgpfsvsceaekrksdyiirtlkvkfns
etrtiyqfhyknwpdhdvpssidpileliwdvrcyqeddsvpicihcsagcgrtgvicai
dytwmllkdgiipenfsvfsliremrtqrpslvqtqeqyelvynavlelfkrqmdvirdk
hsahhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2p6xA (A:)
mdqreilqkfldeaqskkitkeefaneflklkrqstkykadktypttvaekpknikknry
kdilpydysrvelslitdedssyinanfikgvygpkayiatqgplsttlldfwrmiweys
vliivmacmeyemgkkkcerywaepgemqlefgpfsvsceaekrksdyiirtlkvkfnse
trtiyqfhyknwpdhdvpssidpileliwdvrcyqeddsvpicihcsagcgrtgvicaid
ytwmllkdgiipenfsvfsliremrtqrpslvqtqeqyelvynavlelfkrqmdvirdkh
sa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2p6xB (B:)
mdqreilqkfldeaqskkitkeefaneflklkrqstkykadktypttvaekpknikknry
kdilpydysrvelslitsdedssyinanfikgvygpkayiatqgplsttlldfwrmiwey
svliivmacmeyemgkkkcerywaepgemqlefgpfsvsceaekrksdyiirtlkvkfns
etrtiyqfhyknwpdhdvpssidpileliwdvrcyqeddsvpicihcsagcgrtgvicai
dytwmllkdgiipenfsvfsliremrtqrpslvqtqeqyelvynavlelfkrqmdvirdk
hsahhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2p6xB (B:)
qreilqkfldeaqskkitkeefaneflklkrqstkykadktypttvaekpknikknrykd
ilpydysrvelslitsdedssyinanfikgvygpkayiatqgplsttlldfwrmiweysv
liivmacmeyemgkkkcerywaepgemqlefgpfsvsceaekrksdyiirtlkvkfnset
rtiyqfhyknwpdhdvpssidpileliwdvrcyqeddsvpicihcsagcgrtgvicaidy
twmllkdgiipenfsvfsliremrtqrpslvqtqeqyelvynavlelfkrqmdvir