PDB entry 2onz

View 2onz on RCSB PDB site
Description: Structure of K57A hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy
Class: Transferase
Keywords: methyltransferase, Transferase
Deposited on 2007-01-25, released 2007-10-09
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.216
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phenylethanolamine N-methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11086
      • engineered (56)
    Domains in SCOPe 2.04: d2onza_
  • Chain 'B':
    Compound: Phenylethanolamine N-methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11086
      • engineered (56)
    Domains in SCOPe 2.04: d2onzb_
  • Heterogens: SAH, TMJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2onzA (A:)
msgadrspnagaapdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwalrc
laqtfatgevsgrtlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepga
fnwsmysqhacliegkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvs
afcleavspdlasfqraldhittllrpgghllligaleeswylagearltvvpvseeevr
ealvrsgykvrdlrtyimpahlqtgvddvkgvffawaqkvglehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2onzA (A:)
asayqrfepraylrnnyapprgdlcnpngvgpwalrclaqtfatgevsgrtlidigsgpt
vyqllsacshfeditmtdflevnrqelgrwlqeepgafnwsmysqhacliegkgecwqdk
erqlrarvkrvlpidvhqpqplgagspaplpadalvsafcleavspdlasfqraldhitt
llrpgghllligaleeswylagearltvvpvseeevrealvrsgykvrdlrtyimpahlq
tgvddvkgvffawaqkv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2onzB (B:)
msgadrspnagaapdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwalrc
laqtfatgevsgrtlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepga
fnwsmysqhacliegkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvs
afcleavspdlasfqraldhittllrpgghllligaleeswylagearltvvpvseeevr
ealvrsgykvrdlrtyimpahlqtgvddvkgvffawaqkvglehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2onzB (B:)
pdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwalrclaqtfatgevsgr
tlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepgafnwsmysqhacli
egkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvsafcleavspdlas
fqraldhittllrpgghllligaleeswylagearltvvpvseeevrealvrsgykvrdl
rtyimpahlqtgvddvkgvffawaqkvg