PDB entry 2nym

View 2nym on RCSB PDB site
Description: Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit
Class: hydrolase/hydrolase inhibitor
Keywords: HEAT repeat, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on 2006-11-21, released 2006-12-12
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-27, with a file datestamp of 2011-07-22.
Experiment type: XRAY
Resolution: 3.6 Å
R-factor: 0.267
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein phosphatase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2nyma1
  • Chain 'B':
    Compound: serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R5C, KIAA0044
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2nymb1
  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2nymc1
  • Chain 'D':
    Compound: Protein phosphatase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2nymd1
  • Chain 'E':
    Compound: serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R5C, KIAA0044
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2nyme1
  • Chain 'F':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2nymf1
  • Chain 'G':
    Compound: microcystin LR
    Species: Cyanobacteria, synthetic [TaxId:1117]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Chain 'H':
    Compound: microcystin LR
    Species: Cyanobacteria, synthetic [TaxId:1117]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Heterogens: MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nymA (A:)
    dslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
    alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
    fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
    klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
    lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
    efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
    lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
    pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
    amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
    gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nymB (B:)
    qeklfiqklrqccvlfdfvsdplsdlkwkevkraalsemveyithnrnvitepiypevvh
    mfavnmfrtlppssnptgaefdpeedeptleaawphlqlvyefflrflespdfqpniakk
    yidqkfvlqllelfdsedprerdflkttlhriygkflglrayirkqinnifyrfiyeteh
    hngiaelleilgsiingfalplkeehkifllkvllplhkvkslsvyhpqlaycvvqflek
    dstltepvvmallkywpkthspkevmflneleeildviepsefvkimeplfrqlakcvss
    phfqvaeralyywnneyimslisdnaakilpimfpslyrnskthwnktihgliynalklf
    memnqklfddctqqfkaeklkeklkmke
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nymC (C:)
    dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
    fhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesr
    qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
    aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
    qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpapr
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nymD (D:)
    dslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
    alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
    fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
    klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
    lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
    efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
    lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
    pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
    amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
    gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nymE (E:)
    qeklfiqklrqccvlfdfvsdplsdlkwkevkraalsemveyithnrnvitepiypevvh
    mfavnmfrtlppssnptgaefdpeedeptleaawphlqlvyefflrflespdfqpniakk
    yidqkfvlqllelfdsedprerdflkttlhriygkflglrayirkqinnifyrfiyeteh
    hngiaelleilgsiingfalplkeehkifllkvllplhkvkslsvyhpqlaycvvqflek
    dstltepvvmallkywpkthspkevmflneleeildviepsefvkimeplfrqlakcvss
    phfqvaeralyywnneyimslisdnaakilpimfpslyrnskthwnktihgliynalklf
    memnqklfddctqqfkaeklkeklkmke
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nymF (F:)
    dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
    fhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesr
    qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
    aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
    qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpapr
    

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.