PDB entry 2nym

View 2nym on RCSB PDB site
Description: Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit
Class: hydrolase
Keywords: HEAT repeats
Deposited on 2006-11-21, released 2006-12-12
The last revision prior to the SCOP 1.75 freeze date was dated 2007-01-02, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 3.6 Å
R-factor: 0.267
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein phosphatase 2
    Species: HOMO SAPIENS
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96DH3 (0-581)
      • modified residue (172)
      • modified residue (200)
      • modified residue (237)
      • modified residue (254)
      • modified residue (283)
      • modified residue (315)
      • modified residue (342)
      • modified residue (419)
      • modified residue (440)
      • modified residue (481)
      • modified residue (491)
      • modified residue (513)
      • modified residue (520)
    Domains in SCOP 1.75: d2nyma1
  • Chain 'B':
    Compound: serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform
    Species: HOMO SAPIENS
    Gene: PPP2R5C, KIAA0044
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13362 (0-387)
      • modified residue (38)
      • modified residue (60)
      • modified residue (65)
      • modified residue (249)
      • modified residue (265)
      • modified residue (286)
      • modified residue (318)
      • modified residue (332)
      • modified residue (360)
      • modified residue (362)
      • modified residue (385)
    Domains in SCOP 1.75: d2nymb1
  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: HOMO SAPIENS
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2nymc1
  • Chain 'D':
    Compound: Protein phosphatase 2
    Species: HOMO SAPIENS
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96DH3 (0-581)
      • modified residue (172)
      • modified residue (200)
      • modified residue (237)
      • modified residue (254)
      • modified residue (283)
      • modified residue (315)
      • modified residue (342)
      • modified residue (419)
      • modified residue (440)
      • modified residue (481)
      • modified residue (491)
      • modified residue (513)
      • modified residue (520)
    Domains in SCOP 1.75: d2nymd1
  • Chain 'E':
    Compound: serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform
    Species: HOMO SAPIENS
    Gene: PPP2R5C, KIAA0044
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13362 (0-387)
      • modified residue (38)
      • modified residue (60)
      • modified residue (65)
      • modified residue (249)
      • modified residue (265)
      • modified residue (286)
      • modified residue (318)
      • modified residue (332)
      • modified residue (360)
      • modified residue (362)
      • modified residue (385)
    Domains in SCOP 1.75: d2nyme1
  • Chain 'F':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: HOMO SAPIENS
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2nymf1
  • Chain 'G':
    Compound: C-terminal truncated catalytic subunit
  • Chain 'H':
    Compound: C-terminal truncated catalytic subunit
  • Heterogens: MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nymA (A:)
dslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nymB (B:)
qeklfiqklrqccvlfdfvsdplsdlkwkevkraalsemveyithnrnvitepiypevvh
mfavnmfrtlppssnptgaefdpeedeptleaawphlqlvyefflrflespdfqpniakk
yidqkfvlqllelfdsedprerdflkttlhriygkflglrayirkqinnifyrfiyeteh
hngiaelleilgsiingfalplkeehkifllkvllplhkvkslsvyhpqlaycvvqflek
dstltepvvmallkywpkthspkevmflneleeildviepsefvkimeplfrqlakcvss
phfqvaeralyywnneyimslisdnaakilpimfpslyrnskthwnktihgliynalklf
memnqklfddctqqfkaeklkeklkmke

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nymC (C:)
dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
fhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesr
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpapr

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nymD (D:)
dslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nymE (E:)
qeklfiqklrqccvlfdfvsdplsdlkwkevkraalsemveyithnrnvitepiypevvh
mfavnmfrtlppssnptgaefdpeedeptleaawphlqlvyefflrflespdfqpniakk
yidqkfvlqllelfdsedprerdflkttlhriygkflglrayirkqinnifyrfiyeteh
hngiaelleilgsiingfalplkeehkifllkvllplhkvkslsvyhpqlaycvvqflek
dstltepvvmallkywpkthspkevmflneleeildviepsefvkimeplfrqlakcvss
phfqvaeralyywnneyimslisdnaakilpimfpslyrnskthwnktihgliynalklf
memnqklfddctqqfkaeklkeklkmke

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nymF (F:)
dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
fhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesr
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpapr

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.