PDB entry 2ivt

View 2ivt on RCSB PDB site
Description: crystal structure of phosphorylated ret tyrosine kinase domain
Class: transferase
Keywords: nucleotide-binding, hirschsprung disease, phosphorylation, disease mutation, phosphotransferase, tyrosine-protein kinase, chromosomal translocation, polymorphism, gdnf receptor, transmembrane, proto-oncogene, tyrosine kinase, ret, kinase, membrane, ATP-binding, transferase
Deposited on 2006-06-16, released 2006-08-14
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.187
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret precursor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2IVT (0-4)
    • Uniprot P07949 (5-End)
    Domains in SCOPe 2.02: d2ivta_
  • Heterogens: FMT, AMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ivtA (A:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ivtA (A:)
gplslsvdafkipkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkmlke
naspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresrkv
raltmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvyeed
syvkrsqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfnl
lktghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkr