PDB entry 2hw6

View 2hw6 on RCSB PDB site
Description: Crystal structure of Mnk1 catalytic domain
Class: transferase
Keywords: protein kinase, drug design, mnk1, phosphorylation, TRANSFERASE
Deposited on 2006-08-01, released 2006-08-29
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.209
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MAP kinase-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MKNK1, MNK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2hw6a_
  • Chain 'B':
    Compound: MAP kinase-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MKNK1, MNK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2hw6b_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hw6A (A:)
gstdslpgkfedmykltsellgegayakvqgavslqngkeyavkiiekqaghsrsrvfre
vetlyqcqgnknilelieffeddtrfylvfeklqggsilahiqkqkhfnereasrvvrdv
aaaldflhtkgiahrdlkpenilcespekvspvkicdfdlgsgmklnnsctpittpeltt
pcgsaeymapevvevftdqatfydkrcdlwslgvvlyimlsgyppfvghcgadcgwdrge
vcrvcqnklfesiqegkyefpdkdwahisseakdliskllvrdakqrlsaaqvlqhpwvq
gqapekg

    Sequence, based on observed residues (ATOM records): (download) 
    >2hw6A (A:)
slpgkfedmykltsellgegayakvqgavslqngkeyavkiiekqaghsrsrvfrevetl
yqcqgnknilelieffeddtrfylvfeklqggsilahiqkqkhfnereasrvvrdvaaal
dflhtkgiahrdlkpenilcespekvspvkicdfdlgsapevvevftdqatfydkrcdlw
slgvvlyimlsgyppfgkyefpdkdwahisseakdliskllvrdakqrlsaaqvlqhpwv
qg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2hw6B (B:)
gstdslpgkfedmykltsellgegayakvqgavslqngkeyavkiiekqaghsrsrvfre
vetlyqcqgnknilelieffeddtrfylvfeklqggsilahiqkqkhfnereasrvvrdv
aaaldflhtkgiahrdlkpenilcespekvspvkicdfdlgsgmklnnsctpittpeltt
pcgsaeymapevvevftdqatfydkrcdlwslgvvlyimlsgyppfvghcgadcgwdrge
vcrvcqnklfesiqegkyefpdkdwahisseakdliskllvrdakqrlsaaqvlqhpwvq
gqapekg

    Sequence, based on observed residues (ATOM records): (download) 
    >2hw6B (B:)
lpgkfedmykltsellgegayakvqgavslqngkeyavkiiekqaghsrsrvfrevetly
qcqgnknilelieffeddtrfylvfeklqggsilahiqkqkhfnereasrvvrdvaaald
flhtkgiahrdlkpenilcespekvspvkicdfdlgsymapevvevftdqatfydkrcdl
wslgvvlyimlsgyppfwahisseakdliskllvrdakqrlsaaqvlqhpwvq