PDB entry 2hhw

View 2hhw on RCSB PDB site
Description: ddTTP:O6-methyl-guanine pair in the polymerase active site, in the closed conformation
Class: Transferase/DNA
Keywords: DNA polymerase I, DNA replication, Klenow fragment, DNA-protein complex, O6-methyl-guanine, Transferase-DNA COMPLEX
Deposited on 2006-06-28, released 2006-12-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase I
    Species: Geobacillus stearothermophilus [TaxId:1422]
    Gene: polA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2hhwa1, d2hhwa2
  • Chain 'B':
    Compound: 5'-d(*cp*cp*tp*gp*ap*cp*tp*cp*(ddg))-3'
    Species: synthetic, synthetic
  • Chain 'C':
    Compound: 5'-d(*cp*ap*tp*(6og)p*cp*gp*ap*gp*tp*cp*ap*gp*g)-3'
    Species: synthetic, synthetic
  • Chain 'D':
    Compound: DNA polymerase I
    Species: Geobacillus stearothermophilus [TaxId:1422]
    Gene: polA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2hhwd1, d2hhwd2
  • Chain 'E':
    Compound: 5'-d(*cp*cp*tp*gp*ap*cp*tp*cp*(ddg))-3'
    Species: synthetic, synthetic
  • Chain 'F':
    Compound: 5'-d(*cp*ap*tp*(6og)p*cp*gp*ap*gp*tp*cp*ap*gp*g)-3'
    Species: synthetic, synthetic
  • Heterogens: MN, SO4, D3T, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2hhwA (A:)
akmaftladrvteemladkaalvvevveenyhdapivgiavvnehgrfflrpetaladpq
fvawlgdetkkksmfdskraavalkwkgielcgvsfdlllaaylldpaqgvddvaaaakm
kqyeavrpdeavygkgakravpdepvlaehlvrkaaaiwelerpfldelrrneqdrllve
leqplssilaemefagvkvdtkrleqmgkelaeqlgtveqriyelagqefninspkqlgv
ilfeklqlpvlkktktgystsadvleklapyheivenilhyrqlgklqstyiegllkvvr
patkkvhtifnqaltqtgrlsstepnlqnipirleegrkirqafvpsesdwlifaadysq
ielrvlahiaeddnlmeafrrdldihtktamdifqvsedevtpnmrrqakavnygivygi
sdyglaqnlnisrkeaaefieryfesfpgvkrymenivqeakqkgyvttllhrrrylpdi
tsrnfnvrsfaermamntpiqgsaadiikkamidlnarlkeerlqahlllqvhdelilea
pkeemerlcrlvpevmeqavtlrvplkvdyhygstwydak

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2hhwD (D:)
akmaftladrvteemladkaalvvevveenyhdapivgiavvnehgrfflrpetaladpq
fvawlgdetkkksmfdskraavalkwkgielcgvsfdlllaaylldpaqgvddvaaaakm
kqyeavrpdeavygkgakravpdepvlaehlvrkaaaiwelerpfldelrrneqdrllve
leqplssilaemefagvkvdtkrleqmgkelaeqlgtveqriyelagqefninspkqlgv
ilfeklqlpvlkktktgystsadvleklapyheivenilhyrqlgklqstyiegllkvvr
patkkvhtifnqaltqtgrlsstepnlqnipirleegrkirqafvpsesdwlifaadysq
ielrvlahiaeddnlmeafrrdldihtktamdifqvsedevtpnmrrqakavnygivygi
sdyglaqnlnisrkeaaefieryfesfpgvkrymenivqeakqkgyvttllhrrrylpdi
tsrnfnvrsfaermamntpiqgsaadiikkamidlnarlkeerlqahlllqvhdelilea
pkeemerlcrlvpevmeqavtlrvplkvdyhygstwydak

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.