PDB entry 2fqi

View 2fqi on RCSB PDB site
Description: dual binding modes of a novel series of DHODH inhibitors
Class: oxidoreductase
Keywords: protein inhibitor complex, OXIDOREDUCTASE
Deposited on 2006-01-18, released 2007-01-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.185
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2fqia_
  • Heterogens: SO4, ACT, FMN, ORO, ILH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fqiA (A:)
mghhhhhhhhhhssghiddddkhmledpmatgderfyaehlmptlqglldpesahrlavr
ftslgllprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsv
tpkpqegnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvn
lgknktsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqer
dglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrset
gglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltf
wgppvvgkvkreleallkeqgfggvtdaigadhrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2fqiA (A:)
derfyaehlmptlqglldpesahrlavrftslgllprafqdsdmlevrvlghkfrnpvgi
aagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgl
svvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvs
spntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvke
lgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvg
gvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadh
rr