PDB entry 2fie

View 2fie on RCSB PDB site
Description: Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitors
Class: hydrolase
Keywords: allosteric inhibitors human liver FBPase, benzoxazole, intersubunit allosteric inhibitors of human liver FBPase, HYDROLASE
Deposited on 2005-12-29, released 2006-02-21
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.81 Å
R-factor: 0.23
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAH12927
      • variant (217)
    Domains in SCOPe 2.05: d2fiea_
  • Chain 'D':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAH12927
      • variant (217)
    Domains in SCOPe 2.05: d2fied_
  • Chain 'H':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAH12927
      • variant (217)
    Domains in SCOPe 2.05: d2fieh_
  • Chain 'L':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAH12927
      • variant (217)
    Domains in SCOPe 2.05: d2fiel_
  • Heterogens: A74, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fieA (A:)
madqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygi
agstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdp
ldgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdc
gvncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsap
ygaryvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgk
eavldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2fieA (A:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagskldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhsa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2fieD (D:)
madqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygi
agstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdp
ldgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdc
gvncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsap
ygaryvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgk
eavldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2fieD (D:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagskldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhsa

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2fieH (H:)
madqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygi
agstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdp
ldgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdc
gvncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsap
ygaryvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgk
eavldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2fieH (H:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagskldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhsa

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >2fieL (L:)
madqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygi
agstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdp
ldgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdc
gvncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsap
ygaryvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgk
eavldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2fieL (L:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagskldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhsa