PDB entry 2fhy

View 2fhy on RCSB PDB site
Description: Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor
Class: hydrolase
Keywords: allosteric inhibitors human FBPase, benzoxazole, intersubunit allosteric inhibition of human FPBase, HYDROLASE
Deposited on 2005-12-27, released 2006-02-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAH12927
      • variant (253)
    Domains in SCOPe 2.08: d2fhya_
  • Chain 'D':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAH12927
      • variant (253)
    Domains in SCOPe 2.08: d2fhyd_
  • Chain 'H':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAH12927
      • variant (253)
    Domains in SCOPe 2.08: d2fhyh_
  • Chain 'L':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAH12927
      • variant (253)
    Domains in SCOPe 2.08: d2fhyl_
  • Heterogens: MG, A37

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fhyA (A:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdhpftmadqapfdtdvntltrfvmeegrk
argtgeltqllnslctavkaissavrkagiahlygiagstnvtgdqvkkldvlsndlvmn
mlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifgiyrkks
tdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvdkdvkik
kkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlvyggifl
ypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvilgspdd
vleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2fhyA (A:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagskldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2fhyD (D:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdhpftmadqapfdtdvntltrfvmeegrk
argtgeltqllnslctavkaissavrkagiahlygiagstnvtgdqvkkldvlsndlvmn
mlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifgiyrkks
tdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvdkdvkik
kkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlvyggifl
ypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvilgspdd
vleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2fhyD (D:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagskldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhs

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2fhyH (H:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdhpftmadqapfdtdvntltrfvmeegrk
argtgeltqllnslctavkaissavrkagiahlygiagstnvtgdqvkkldvlsndlvmn
mlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifgiyrkks
tdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvdkdvkik
kkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlvyggifl
ypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvilgspdd
vleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2fhyH (H:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagskldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhs

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >2fhyL (L:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdhpftmadqapfdtdvntltrfvmeegrk
argtgeltqllnslctavkaissavrkagiahlygiagstnvtgdqvkkldvlsndlvmn
mlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifgiyrkks
tdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvdkdvkik
kkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlvyggifl
ypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvilgspdd
vleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2fhyL (L:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagskldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhs