PDB entry 2cle

View 2cle on RCSB PDB site
Description: tryptophan synthase in complex with n-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (f6)-lowf6 complex
Class: lyase
Keywords: aromatic amino acid biosynthesis, tryptophan biosynthesis, crbon- oxygen lyase, amino-acid biosynthesis, lyase, allosteric enzyme, pyridoxal phosphate
Deposited on 2006-04-27, released 2007-06-12
The last revision prior to the SCOP 1.75 freeze date was dated 2007-07-03, with a file datestamp of 2007-06-29.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.194
AEROSPACI score: 0.72 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tryptophan synthase alpha chain
    Species: SALMONELLA TYPHIMURIUM
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2clea1
  • Chain 'B':
    Compound: tryptophan synthase beta chain
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A2K1 (0-End)
      • conflict (32)
    Domains in SCOP 1.75: d2cleb1
  • Heterogens: NA, F6F, PLP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2cleA (A:)
meryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdplad
gptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceq
vgvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllsrs
gvtgaenrgalplhhlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivki
ieknlaspkqmlaelrsfvsamkaasra

    Sequence, based on observed residues (ATOM records): (download) 
    >2cleA (A:)
eryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdpladg
ptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceqv
gvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllshhl
ieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivkiieknlaspkqmlaelr
sfvsamkaasra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2cleB (B:)
ttllnpyfgefggmyvpqilmpalnqleeafvraqkdpefqaqfadllknyagrptaltk
cqnitagtrttlylkredllhggahktnqvlgqallakrmgkseiiaetgagqhgvasal
asallglkcriymgakdverqspnvfrmrlmgaevipvhsgsatlkdacnealrdwsgsy
etahymlgtaagphpyptivrefqrmigeetkaqildkegrlpdaviacvgggsnaigmf
adfindtsvgligvepgghgietgehgaplkhgrvgiyfgmkapmmqtadgqieesysis
agldfpsvgpqhaylnsigradyvsitddealeafktlcrhegiipalesshalahalkm
mreqpekeqllvvnlsgrgdkdiftvhdilkargei

    Sequence, based on observed residues (ATOM records): (download) 
    >2cleB (B:)
ttllnpyfgefggmyvpqilmpalnqleeafvraqkdpefqaqfadllknyagrptaltk
cqnitagtrttlylkredllhggahktnqvlgqallakrmgkseiiaetgagqhgvasal
asallglkcriymgakdverqspnvfrmrlmgaevipvhsgsatlkdacnealrdwsgsy
etahymlgtaagphpyptivrefqrmigeetkaqildkegrlpdaviacvgggsnaigmf
adfindtsvgligvepgghgietgehgaplkhgrvgiyfgmkapmmqtadgqieesysis
agldfpsvgpqhaylnsigradyvsitddealeafktlcrhegiipalesshalahalkm
mreqpekeqllvvnlsgrgdkdiftvhdilkarge