PDB entry 2bfo

View 2bfo on RCSB PDB site
Description: leishmania major pteridine reductase 1 in complex with nadph
Class: oxidoreductase
Keywords: pteridine reductase, trypanosomatids, drug resistance, pterin salvage, short-chain dehydrogenase/reductase, methotrexate resistance, nadp, oxidoreductase
Deposited on 2004-12-10, released 2005-08-31
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.229
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pteridine reductase 1
    Species: Leishmania major [TaxId:5664]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d2bfoa_
  • Chain 'B':
    Compound: pteridine reductase 1
    Species: Leishmania major [TaxId:5664]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d2bfob_
  • Chain 'C':
    Compound: pteridine reductase 1
    Species: Leishmania major [TaxId:5664]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d2bfoc_
  • Chain 'D':
    Compound: pteridine reductase 1
    Species: Leishmania major [TaxId:5664]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d2bfod_
  • Heterogens: NDP, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2bfoA (A:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >2bfoA (A:)
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapvapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrgdreametata
dlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgal
egltrsaalelaplqirvngvgpglsvlvddmppavweghrskvplyqrdssaaevsdvv
iflcsskakyitgtcvkvdggysltra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2bfoB (B:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >2bfoB (B:)
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapvapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrnreametatad
lfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgale
gltrsaalelaplqirvngvgpglsvlvddmppavweghrskvplyqrdssaaevsdvvi
flcsskakyitgtcvkvdggysltra

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2bfoC (C:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >2bfoC (C:)
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrdreametatadlfg
snaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgaleglt
rsaalelaplqirvngvgpglsvlvdghrskvplyqrdssaaevsdvviflcsskakyit
gtcvkvdggysltra

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2bfoD (D:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >2bfoD (D:)
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrreametatadl
fgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgaleg
ltrsaalelaplqirvngvgpglsvlvghrskvplyqrdssaaevsdvviflcsskakyi
tgtcvkvdggysltra