PDB entry 2bel

View 2bel on RCSB PDB site
Description: structure of human 11-beta-hydroxysteroid dehydrogenase in complex with nadp and carbenoxolone
Class: oxidoreductase
Keywords: oxidoreductase, glucocorticoid activation, drug target, inhibitor, short-chain dehydrogenase/reductase, hormone metabolism, microsome, nadp, steroid metabolism
Deposited on 2004-11-25, released 2004-12-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: 0.19
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BEL
    • Uniprot P28845 (22-End)
    Domains in SCOPe 2.06: d2bela_
  • Chain 'B':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2belb_
  • Chain 'C':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BEL
    • Uniprot P28845 (22-End)
    Domains in SCOPe 2.06: d2belc1, d2belc2
  • Chain 'D':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BEL
    • Uniprot P28845 (22-End)
    Domains in SCOPe 2.06: d2beld1, d2beld2
  • Heterogens: NAP, CBO, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2belA (A:)
gsshhhhhhssgrenlyfqghmefrpemlqgkkvivtgaskgigremayhlakmgahvvv
tarsketlqkvvshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitn
tslnlfhddihhvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaay
saskfaldgffssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecal
eiikggalrqeevyydsslwttllirnpcrkileflystsygs

    Sequence, based on observed residues (ATOM records): (download) 
    >2belA (A:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
lli

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2belB (B:)
gsshhhhhhssgrenlyfqghmefrpemlqgkkvivtgaskgigremayhlakmgahvvv
tarsketlqkvvshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitn
tslnlfhddihhvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaay
saskfaldgffssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecal
eiikggalrqeevyydsslwttllirnpcrkileflystsygs

    Sequence, based on observed residues (ATOM records): (download) 
    >2belB (B:)
frpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaasa
hyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfls
yvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsrv
nvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwttl
lirnpcrkile

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2belC (C:)
gsshhhhhhssgrenlyfqghmefrpemlqgkkvivtgaskgigremayhlakmgahvvv
tarsketlqkvvshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitn
tslnlfhddihhvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaay
saskfaldgffssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecal
eiikggalrqeevyydsslwttllirnpcrkileflystsygs

    Sequence, based on observed residues (ATOM records): (download) 
    >2belC (C:)
grenlyfqghmefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkv
vshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddih
hvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgff
ssirkeysvsrvnvsitlcvlglidtetamkavsgmqaapkeecaleiikggalrqeevy
ydsslwttllirnp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2belD (D:)
gsshhhhhhssgrenlyfqghmefrpemlqgkkvivtgaskgigremayhlakmgahvvv
tarsketlqkvvshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitn
tslnlfhddihhvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaay
saskfaldgffssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecal
eiikggalrqeevyydsslwttllirnpcrkileflystsygs

    Sequence, based on observed residues (ATOM records): (download) 
    >2belD (D:)
mefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaa
sahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnf
lsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvs
rvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwt
tllirnpcrkile