PDB entry 2b5t
View 2b5t on RCSB PDB site
Description: 2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules
Class: Blood Clotting
Keywords: Blood coagulation, Blood Clotting
Deposited on
2005-09-29, released
2006-09-19
The last revision prior to the SCOPe 2.03 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-25.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.209
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: thrombin
Species: Homo sapiens [TaxId:9606]
Gene: F2
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: thrombin
Species: Homo sapiens [TaxId:9606]
Gene: F2
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: thrombin
Species: Homo sapiens [TaxId:9606]
Gene: F2
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: thrombin
Species: Homo sapiens [TaxId:9606]
Gene: F2
Database cross-references and differences (RAF-indexed):
- Chain 'I':
Compound: antithrombin-III
Species: Homo sapiens [TaxId:9606]
Gene: SERPINC1, AT3
Database cross-references and differences (RAF-indexed):
- Uniprot P01008
- engineered (136)
- engineered (316)
- engineered (400)
Domains in SCOPe 2.03: d2b5ti_ - Heterogens: GOL, SO4, NAG, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
No sequence available.
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.
- Chain 'I':
Sequence, based on SEQRES records: (download)
>2b5tI (I:)
hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
fffaklncrlyrkankasklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
pevlqewldeleemmlcvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
dlyvsdafhkaflevneegseaaastavviagrslnpnrvcfkanrpflvfirevplnti
ifmgrvanpcvk
Sequence, based on observed residues (ATOM records): (download)
>2b5tI (I:)
dictakprdipmnpmciyrspekipeatnrrvwelskansrfattfyqhladskndndni
flsplsistafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkank
asklvsanrlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnkteg
ritdvipseaineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqeg
kfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemml
cvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkaflevn
eegseaaastavviagrslnpnrvcfkanrpflvfirevplntiifmgrvanpcv