PDB entry 2b4c

View 2b4c on RCSB PDB site
Description: Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody
Class: Viral protein/Immune system
Keywords: HIV-1, gp120, JRFL, V3, X5, CD4 induced antibody, Viral protein-Immune system COMPLEX
Deposited on 2005-09-23, released 2005-11-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: T-cell surface glycoprotein cd4
    Species: Homo sapiens [TaxId:9606]
    Gene: CD4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2b4cc1, d2b4cc2
  • Chain 'G':
    Compound: Envelope glycoprotein
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
    • GB AAB05604 (5-48)
    • GB AAB05604 (52-343)
    Domains in SCOPe 2.08: d2b4cg1
  • Chain 'H':
    Compound: anti-HIV-1 gp120 immunoglobulin X5 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2B4C (Start-234)
    Domains in SCOPe 2.08: d2b4ch1, d2b4ch2
  • Chain 'L':
    Compound: anti-HIV-1 gp120 immunoglobulin X5 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2B4C (0-214)
    Domains in SCOPe 2.08: d2b4cl1, d2b4cl2
  • Heterogens: NAG, SO4, XYL

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2b4cC (C:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
k

    Sequence, based on observed residues (ATOM records): (download) 
    >2b4cC (C:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidiv

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2b4cG (G:)
garsevvlenvtehfnmwkndmveqmqediislwdqslkpcvkltplcvgagscdtsvit
qacpkisfepipihycapagfailkcndktfngkgpcknvstvqcthgirpvvstqllln
gslaeeevvirsdnftnnaktiivqlkesveinctrpnqntrksihigpgrafyttgeii
gdirqahcnisrakwndtlkqiviklreqfenktivfnhssggdpeivmhsfncggeffy
cnsaqlfnstwnnntegsnntegntitlpcrikqiinmwqevgkamyappirgqircssn
itgllltrdgginengteifrpgggdmrdnwrselykykvvkie

    Sequence, based on observed residues (ATOM records): (download) 
    >2b4cG (G:)
vvlenvtehfnmwkndmveqmqediislwdqslkpcvkltplcvgagscdtsvitqacpk
isfepipihycapagfailkcndktfngkgpcknvstvqcthgirpvvstqlllngslae
eevvirsdnftnnaktiivqlkesveinctrpnqntrksihigpgrafyttgeiigdirq
ahcnisrakwndtlkqiviklreqfenktivfnhssggdpeivmhsfncggeffycnsaq
lfnstwnnntegsnntegntitlpcrikqiinmwqevgkamyappirgqircssnitgll
ltrdgginengteifrpgggdmrdnwrselykykvvkie

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2b4cH (H:)
evqlleqsgaevkkpgssvqvsckasggtfsmygfnwvrqapghglewmggiipifgtsn
yaqkfrgrvtftadqatstaymeltnlrsddtavyycardfgpdwedgdsydgsgrgffd
fwgqgtlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >2b4cH (H:)
qlleqsgaevkkpgssvqvsckasggtfsmygfnwvrqapghglewmggiipifgtsnya
qkfrgrvtftadqatstaymeltnlrsddtavyycardfgpdwedgdsydgsgrgffdfw
gqgtlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgv
htfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2b4cL (L:)
elvltqspgtlslsageratlscrasqsvssgslawyqqkpgqaprlliygastratgip
drfsgsgsgtdftltigrlepedlavyycqqygtspytfgqgtkleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsrdstyslgstl
tlskadyekhkvyacevthqglsspvtksfnrgec