PDB entry 2b0m

View 2b0m on RCSB PDB site
Description: Human dihydroorotate dehydrogenase bound to a novel inhibitor
Class: oxidoreductase
Keywords: TIM barrel; alpha/beta barrel, OXIDOREDUCTASE
Deposited on 2005-09-14, released 2005-09-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-03-24, with a file datestamp of 2009-03-20.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.218
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2b0ma_
  • Heterogens: 201, FMN, ORO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2b0mA (A:)
    mghhhhhhhhhhssghiddddkhmlematgderfyaehlmptlqglldpesahrlavrft
    slgllprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsvtp
    kpqegnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvnlg
    knktsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqerdg
    lrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrsetgg
    lsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltfwg
    ppvvgkvkreleallkeqgfggvtdaigadhrr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b0mA (A:)
    gderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpvgia
    agfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgls
    vvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvss
    pntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkel
    gidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvgg
    vssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhr
    r