PDB entry 2apq

View 2apq on RCSB PDB site
Description: Crystal Structure of an Active Site Mutant of Bovine Pancreatic Ribonuclease A (H119A-RNase A) with a 10-Glutamine expansion in the C-terminal hinge-loop.
Class: hydrolase
Keywords: An active site mutant of RNase A (H119A) with an amyloidogenic expansion in the C-terminal hinge-loop region(between residues 112 and 113)., HYDROLASE
Deposited on 2005-08-16, released 2005-09-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.181
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribonuclease
    Species: Bos taurus [TaxId:9913]
    Gene: RNASE1, RNS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61823 (3-138)
      • insertion (114)
      • engineered (133)
    Domains in SCOPe 2.07: d2apqa_
  • Heterogens: PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2apqA (A:)
    amaketaaakferqhmdsstsaasssnycnqmmksrnltkdrckpvntfvhesladvqav
    csqknvackngqtncyqsystmsitdcretgsskypncaykttqankhiivaceggqqqq
    qqqqqqgnpyvpvafdasv
    

    Sequence, based on observed residues (ATOM records): (download)
    >2apqA (A:)
    ketaaakferqhmdsstsaasssnycnqmmksrnltkdrckpvntfvhesladvqavcsq
    knvackngqtncyqsystmsitdcretgsskypncaykttqankhiivacegyvpvafda
    sv