PDB entry 2an3

View 2an3 on RCSB PDB site
Description: Structure of PNMT with S-adenosyl-L-homocysteine and the semi-rigid analogue acceptor substrate cis-(1R,2S)-2-amino-1-tetralol.
Class: transferase
Keywords: methyltransferase, substrate structure, S-adenosyl-L-methionine, adrenaline synthesis, TRANSFERASE
Deposited on 2005-08-11, released 2006-03-14
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.217
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phenylethanolamine N-methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNMT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2an3a_
  • Chain 'B':
    Compound: Phenylethanolamine N-methyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNMT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2an3b_
  • Heterogens: SAH, CTL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2an3A (A:)
msgadrspnagaapdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwklrc
laqtfatgevsgrtlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepga
fnwsmysqhacliegkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvs
afcleavspdlasfqraldhittllrpgghllligaleeswylagearltvvpvseeevr
ealvrsgykvrdlrtyimpahlqtgvddvkgvffawaqkvglehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2an3A (A:)
vasayqrfepraylrnnyapprgdlcnpngvgpwklrclaqtfatgevsgrtlidigsgp
tvyqllsacshfeditmtdflevnrqelgrwlqeepgafnwsmysqhacliegkgecwqd
kerqlrarvkrvlpidvhqpqplgagspaplpadalvsafcleavspdlasfqraldhit
tllrpgghllligaleeswylagearltvvpvseeevrealvrsgykvrdlrtyimpahl
qtgvddvkgvffawaqkv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2an3B (B:)
msgadrspnagaapdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwklrc
laqtfatgevsgrtlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepga
fnwsmysqhacliegkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvs
afcleavspdlasfqraldhittllrpgghllligaleeswylagearltvvpvseeevr
ealvrsgykvrdlrtyimpahlqtgvddvkgvffawaqkvglehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2an3B (B:)
apdsapgqaavasayqrfepraylrnnyapprgdlcnpngvgpwklrclaqtfatgevsg
rtlidigsgptvyqllsacshfeditmtdflevnrqelgrwlqeepgafnwsmysqhacl
iegkgecwqdkerqlrarvkrvlpidvhqpqplgagspaplpadalvsafcleavspdla
sfqraldhittllrpgghllligaleeswylagearltvvpvseeevrealvrsgykvrd
lrtyimpahlqtgvddvkgvffawaqkvg