PDB entry 2aer

View 2aer on RCSB PDB site
Description: Crystal Structure of Benzamidine-Factor VIIa/Soluble Tissue Factor complex.
Class: blood clotting
Keywords: Serine Protease, calcium, Magnesium, Zinc, Sodium, Factor VIIa, Tissue Factor, Benzamidine, blood coagulation, clotting, blood, coagulation, clotting factor, coagulation factor, BLOOD CLOTTING
Deposited on 2005-07-23, released 2006-07-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.87 Å
R-factor: 0.191
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2aerh_
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08709 (0-141)
      • modified residue (5-6)
      • modified residue (13)
      • modified residue (15)
      • modified residue (18-19)
      • modified residue (24-25)
      • modified residue (28)
      • modified residue (34)
    Domains in SCOPe 2.07: d2aerl1, d2aerl2, d2aerl3
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13726 (1-205)
      • cloning artifact (0)
    Domains in SCOPe 2.07: d2aert1, d2aert2, d2aert3
  • Heterogens: GLC, FUC, MG, CA, NA, ZN, CL, BEN, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2aerH (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
    sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
    seprpgvllrapfp
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2aerL (L:)
    anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
    ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
    ladgvsctptveypcgkipile
    

  • Chain 'T':
    Sequence, based on SEQRES records: (download)
    >2aerT (T:)
    atvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeiv
    kdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgtkvn
    vtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdkgen
    ycfsvqavipsrtvnrkstdspvecm
    

    Sequence, based on observed residues (ATOM records): (download)
    >2aerT (T:)
    atvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeiv
    kdvkqtylarvfsypagngeplyenspeftpyletnlgqptiqsfeqvgtkvnvtveder
    tlvrrnntflslrdvfgkdliytlyywktaktntneflidvdkgenycfsvqavipsrtv
    nrkstdspvecm