PDB entry 1w72

View 1w72 on RCSB PDB site
Description: crystal structure of hla-a1:mage-a1 in complex with fab-hyb3
Class: immune system
Keywords: immune system, hla/fab fragment, human leucocyte antigen, peptide-specific fab, tcr-like binding, MHC-I
Deposited on 2004-08-27, released 2004-11-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.186
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class I histocompatibility antigen
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1w72a1, d1w72a2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • expression tag (0)
    Domains in SCOPe 2.07: d1w72b1, d1w72b2
  • Chain 'C':
    Compound: melanoma-associated antigen 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: hla class I histocompatibility antigen
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1w72d1, d1w72d2
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • expression tag (0)
    Domains in SCOPe 2.07: d1w72e1, d1w72e2
  • Chain 'F':
    Compound: melanoma-associated antigen 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: hyb3 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1W72 (0-222)
    Domains in SCOPe 2.07: d1w72h1, d1w72h2
  • Chain 'I':
    Compound: hyb3 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1W72 (0-222)
    Domains in SCOPe 2.07: d1w72i1, d1w72i2
  • Chain 'L':
    Compound: hyb3 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1W72 (0-209)
    Domains in SCOPe 2.07: d1w72l1, d1w72l2
  • Chain 'M':
    Compound: hyb3 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1W72 (0-209)
    Domains in SCOPe 2.07: d1w72m1, d1w72m2
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1w72A (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqkmeprapwieqegpeyw
    dqetrnmkahsqtdranlgtlrgyynqsedgshtiqimygcdvgpdgrflrgyrqdaydg
    kdyialnedlrswtaadmaaqitkrkweavhaaeqrrvylegrcvdglrrylengketlq
    rtdppkthmthhpisdheatlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgeeqrytchvqheglpkpltlrw
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1w72B (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1w72D (D:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqkmeprapwieqegpeyw
    dqetrnmkahsqtdranlgtlrgyynqsedgshtiqimygcdvgpdgrflrgyrqdaydg
    kdyialnedlrswtaadmaaqitkrkweavhaaeqrrvylegrcvdglrrylengketlq
    rtdppkthmthhpisdheatlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgeeqrytchvqheglpkpltlrw
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1w72E (E:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'F':
    No sequence available.

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1w72H (H:)
    evqlvesggglvqpgrslrlscaasgftfddyamhwvrqapgkglewvsgiswnsgsigy
    adsvkgrftisrdnaknslylqmnslraedtavyycargrgfhyyyygmdiwgqgttvtv
    ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
    ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
    

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1w72I (I:)
    evqlvesggglvqpgrslrlscaasgftfddyamhwvrqapgkglewvsgiswnsgsigy
    adsvkgrftisrdnaknslylqmnslraedtavyycargrgfhyyyygmdiwgqgttvtv
    ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
    ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1w72L (L:)
    syvltqppsvsvapgqtaritcggnnigsrsvhwyqqkpgqapvlvvyddsdrpsgiper
    fsgsnsgnmatltisrveagdeadyycqvwdsrtdhwvfgggtdltvlgqpkaapsvtlf
    ppsseelqankatlvclisdfypgavtvawkadgspvkagvettkpskqsnnkyaassyl
    sltpeqwkshrsyscqvthegstvektvap
    

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1w72M (M:)
    syvltqppsvsvapgqtaritcggnnigsrsvhwyqqkpgqapvlvvyddsdrpsgiper
    fsgsnsgnmatltisrveagdeadyycqvwdsrtdhwvfgggtdltvlgqpkaapsvtlf
    ppsseelqankatlvclisdfypgavtvawkadgspvkagvettkpskqsnnkyaassyl
    sltpeqwkshrsyscqvthegstvektvap