PDB entry 1w6j

View 1w6j on RCSB PDB site
Description: structure of human osc in complex with ro 48-8071
Class: isomerase
Keywords: cyclase, cholesterol, lanosterol, monotopic membrane protein, b-octyl-glucoside, isomerase, steroid biosynthesis
Deposited on 2004-08-18, released 2004-10-29
The last revision prior to the SCOP 1.73 freeze date was dated 2004-10-29, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.17134
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lanosterol synthase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1w6ja1, d1w6ja2
  • Heterogens: BOG, R71, C14, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1w6jA (A:)
mtegtclrrrggpyktepatdlgrwrlncergrqtwtylqderagreqtgleayalgldt
knyfkdlpkahtafegalngmtfyvglqaedghwtgdyggplfllpgllitchvariplp
agyreeivrylrsvqlpdggwglhiedkstvfgtalnyvslrilgvgpddpdlvrarnil
hkkggavaipswgkfwlavlnvysweglntlfpemwlfpdwapahpstlwchcrqvylpm
sycyavrlsaaedplvqslrqelyvedfasidwlaqrnnvapdelytphswllrvvyall
nlyehhhsahlrqravqklyehivaddrftksisigpisktinmlvrwyvdgpastafqe
hvsripdylwmgldgmkmqgtngsqiwdtafaiqalleagghhrpefssclqkaheflrl
sqvpdnppdyqkyyrqmrkggfsfstldcgwivsdctaealkavlllqekcphvtehipr
erlcdavavllnmrnpdggfatyetkrgghllellnpsevfgdimidytyvectsavmqa
lkyfhkrfpehraaeiretltqglefcrrqqradgswegswgvcftygtwfgleafacmg
qtyrdgtacaevsracdfllsrqmadggwgedfesceerrylqsaqsqihntcwammglm
avrhpdieaqergvrcllekqlpngdwpqeniagvfnkscaisytsyrnifpiwalgrfs
qlyperalaghp

    Sequence, based on observed residues (ATOM records): (download) 
    >1w6jA (A:)
clrrrggpyktepatdlgrwrlncergrqtwtylqderagreqtgleayalgldtknyfk
dlpkahtafegalngmtfyvglqaedghwtgdyggplfllpgllitchvariplpagyre
eivrylrsvqlpdggwglhiedkstvfgtalnyvslrilgvgpddpdlvrarnilhkkgg
avaipswgkfwlavlnvysweglntlfpemwlfpdwapahpstlwchcrqvylpmsycya
vrlsaaedplvqslrqelyvedfasidwlaqrnnvapdelytphswllrvvyallnlyeh
hhsahlrqravqklyehivaddrftksisigpisktinmlvrwyvdgpastafqehvsri
pdylwmgldgmkmqgtngsqiwdtafaiqalleagghhrpefssclqkaheflrlsqvpd
nppdyqkyyrqmrkggfsfstldcgwivsdctaealkavlllqekcphvtehiprerlcd
avavllnmrnpdggfatyetkrgghllellnpsevfgdimidytyvectsavmqalkyfh
krfpehraaeiretltqglefcrrqqradgswegswgvcftygtwfgleafacmgqtyrd
gtacaevsracdfllsrqmadggwgedfesceerrylqsaqsqihntcwammglmavrhp
dieaqergvrcllekqlpngdwpqeniagvfnkscaisytsyrnifpiwalgrfsqlype
ralaghp