PDB entry 1umd

View 1umd on RCSB PDB site
Description: branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8 with 4-methyl-2-oxopentanoate as an intermediate
Class: Oxidoreductase
Keywords: alpha(2)beta(2) tetramer, structural genomics, RIKEN Structural Genomics/Proteomics Initiative, RSGI, Oxidoreductase
Deposited on 2003-09-25, released 2004-03-30
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.172
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-oxo acid dehydrogenase alpha subunit
    Species: Thermus thermophilus [TaxId:274]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1umda_
  • Chain 'B':
    Compound: 2-oxo acid dehydrogenase beta subunit
    Species: Thermus thermophilus [TaxId:274]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1umdb1, d1umdb2
  • Chain 'C':
    Compound: 2-oxo acid dehydrogenase alpha subunit
    Species: Thermus thermophilus [TaxId:274]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1umdc_
  • Chain 'D':
    Compound: 2-oxo acid dehydrogenase beta subunit
    Species: Thermus thermophilus [TaxId:274]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1umdd1, d1umdd2
  • Heterogens: MG, TDP, COI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1umdA (A:)
mvkethrfetfteepirligeegewlgdfpldlegeklrrlyrdmlaarmlderytilir
tgktsfiapaagheaaqvaiahairpgfdwvfpyyrdhglalalgiplkellgqmlatka
dpnkgrqmpehpgskalnfftvaspiashvppaagaaismkllrtgqvavctfgdgatse
gdwyaginfaavqgapavfiaennfyaisvdyrhqthsptiadkahafgipgylvdgmdv
lasyyvvkeaverarrgegpslvelrvyrygphssadddsryrpkeevafwrkkdpiprf
rrflearglwneeweedvreeiraelerglkeaeeagpvppewmfedvfaekpwhllrqe
allkeel

    Sequence, based on observed residues (ATOM records): (download) 
    >1umdA (A:)
hrfetfteepirligeegewlgdfpldlegeklrrlyrdmlaarmlderytilirtgkts
fiapaagheaaqvaiahairpgfdwvfpyyrdhglalalgiplkellgqmlatkadpnkg
rqmpehpgskalnfftvaspiashvppaagaaismkllrtgqvavctfgdgatsegdwya
ginfaavqgapavfiaennfyaisvdyrhqthsptiadkahafgipgylvdgmdvlasyy
vvkeaverarrgegpslvelrvyrygphssadddsryrpkeevafwrkkdpiprfrrfle
arglwneeweedvreeiraelerglkeaeeagpvppewmfedvfaekpwhllrqeallke
el

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1umdB (B:)
malmtmvqalnraldeemakdprvvvlgedvgkrggvflvtegllqkygpdrvmdtplse
aaivgaalgmaahglrpvaeiqfadyifpgfdqlvsqvaklryrsggqftaplvvrmpsg
ggvrgghhhsqspeahfvhtaglkvvavstpydakgllkaairdedpvvflepkrlyrsv
keevpeedytlpigkaalrregkdltlicygtvmpevlqaaaelakagvsaevldlrtlm
pwdyeavmnsvaktgrvvlvsdaprhasfvsevaatiaedlldmllappirvtgfdtpyp
yaqdklylptvtrilnaakraldy

    Sequence, based on observed residues (ATOM records): (download) 
    >1umdB (B:)
almtmvqalnraldeemakdprvvvlgedvgkrggvflvtegllqkygpdrvmdtplsea
aivgaalgmaahglrpvaeiqfadyifpgfdqlvsqvaklryrsggqftaplvvrmpsgg
gvrgghhhsqspeahfvhtaglkvvavstpydakgllkaairdedpvvflepkrlyrsvk
eevpeedytlpigkaalrregkdltlicygtvmpevlqaaaelakagvsaevldlrtlmp
wdyeavmnsvaktgrvvlvsdaprhasfvsevaatiaedlldmllappirvtgfdtpypy
aqdklylptvtrilnaakraldy

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1umdC (C:)
mvkethrfetfteepirligeegewlgdfpldlegeklrrlyrdmlaarmlderytilir
tgktsfiapaagheaaqvaiahairpgfdwvfpyyrdhglalalgiplkellgqmlatka
dpnkgrqmpehpgskalnfftvaspiashvppaagaaismkllrtgqvavctfgdgatse
gdwyaginfaavqgapavfiaennfyaisvdyrhqthsptiadkahafgipgylvdgmdv
lasyyvvkeaverarrgegpslvelrvyrygphssadddsryrpkeevafwrkkdpiprf
rrflearglwneeweedvreeiraelerglkeaeeagpvppewmfedvfaekpwhllrqe
allkeel

    Sequence, based on observed residues (ATOM records): (download) 
    >1umdC (C:)
hrfetfteepirligeegewlgdfpldlegeklrrlyrdmlaarmlderytilirtgkts
fiapaagheaaqvaiahairpgfdwvfpyyrdhglalalgiplkellgqmlatkadpnkg
rqmpehpgskalnfftvaspiashvppaagaaismkllrtgqvavctfgdgatsegdwya
ginfaavqgapavfiaennfyaisvdyrhqthsptiadkahafgipgylvdgmdvlasyy
vvkeaverarrgegpslvelrvyrygphssadddsryrpkeevafwrkkdpiprfrrfle
arglwneeweedvreeiraelerglkeaeeagpvppewmfedvfaekpwhllrqeallke
e

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1umdD (D:)
malmtmvqalnraldeemakdprvvvlgedvgkrggvflvtegllqkygpdrvmdtplse
aaivgaalgmaahglrpvaeiqfadyifpgfdqlvsqvaklryrsggqftaplvvrmpsg
ggvrgghhhsqspeahfvhtaglkvvavstpydakgllkaairdedpvvflepkrlyrsv
keevpeedytlpigkaalrregkdltlicygtvmpevlqaaaelakagvsaevldlrtlm
pwdyeavmnsvaktgrvvlvsdaprhasfvsevaatiaedlldmllappirvtgfdtpyp
yaqdklylptvtrilnaakraldy

    Sequence, based on observed residues (ATOM records): (download) 
    >1umdD (D:)
almtmvqalnraldeemakdprvvvlgedvgkrggvflvtegllqkygpdrvmdtplsea
aivgaalgmaahglrpvaeiqfadyifpgfdqlvsqvaklryrsggqftaplvvrmpsgg
gvrgghhhsqspeahfvhtaglkvvavstpydakgllkaairdedpvvflepkrlyrsvk
eevpeedytlpigkaalrregkdltlicygtvmpevlqaaaelakagvsaevldlrtlmp
wdyeavmnsvaktgrvvlvsdaprhasfvsevaatiaedlldmllappirvtgfdtpypy
aqdklylptvtrilnaakraldy