PDB entry 1qdu
View 1qdu on RCSB PDB site
Description: crystal structure of the complex of caspase-8 with the tripeptide ketone inhibitor zevd-dcbmk
Class: hydrolase/hydrolase inhibitor
Keywords: apoptosis, cysteine protease, hydrolase-hydrolase inhibitor complex
Deposited on
1999-07-10, released
2000-07-10
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-10-04, with a file datestamp of
2017-09-29.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.14
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: caspase-8 alpha-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.1 - Chain 'B':
Compound: caspase-8 beta-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.1 - Chain 'C':
Compound: caspase-8 alpha-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.2 - Chain 'D':
Compound: caspase-8 beta-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.2 - Chain 'E':
Compound: caspase-8 alpha-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.3 - Chain 'F':
Compound: caspase-8 beta-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.3 - Chain 'G':
Compound: caspase-8 alpha-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.4 - Chain 'H':
Compound: caspase-8 beta-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.4 - Chain 'I':
Compound: caspase-8 alpha-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.5 - Chain 'J':
Compound: caspase-8 beta-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.5 - Chain 'K':
Compound: caspase-8 alpha-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.6 - Chain 'L':
Compound: caspase-8 beta-chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1qdu.6 - Chain 'T':
Compound: phq-glu-val-asp-dichloromethylketone inhibitor
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'U':
Compound: phq-glu-val-asp-dichloromethylketone inhibitor
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'V':
Compound: phq-glu-val-asp-dichloromethylketone inhibitor
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'W':
Compound: phq-glu-val-asp-dichloromethylketone inhibitor
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'X':
Compound: phq-glu-val-asp-dichloromethylketone inhibitor
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'Y':
Compound: phq-glu-val-asp-dichloromethylketone inhibitor
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduA (A:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduB (B:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduC (C:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduD (D:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp
- Chain 'E':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduE (E:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd
- Chain 'F':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduF (F:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp
- Chain 'G':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduG (G:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduH (H:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp
- Chain 'I':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduI (I:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd
- Chain 'J':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduJ (J:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp
- Chain 'K':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduK (K:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>1qduL (L:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp
- Chain 'T':
No sequence available.
- Chain 'U':
No sequence available.
- Chain 'V':
No sequence available.
- Chain 'W':
No sequence available.
- Chain 'X':
No sequence available.
- Chain 'Y':
No sequence available.