PDB entry 1pzl

View 1pzl on RCSB PDB site
Description: Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide
Class: transcription
Keywords: transcription
Deposited on 2003-07-11, released 2004-06-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.226
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hepatocyte nuclear factor 4-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: HNF4a
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41235 (Start-236)
      • engineered (4-5)
    Domains in SCOPe 2.08: d1pzla_
  • Chain 'B':
    Compound: steroid receptor coactivator-1
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • GB AAB50242 (0-13)
    Domains in SCOPe 2.08: d1pzlb_
  • Heterogens: MYR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1pzlA (A:)
ssyelaslpsinallqaevlsrqitspvsgingdirakkiasiadvcesmkeqllvlvew
akyipafcelplddqvallrahagehlllgatkrsmvfkdvlllgndyivprhcpelaem
srvsirildelvlpfqelqiddneyaylkaiiffdpdakglsdpgkikrlrsqvqvsled
yindrqydsrgrfgelllllptlqsitwqmieqiqfiklfgmakidnllqemllggs

    Sequence, based on observed residues (ATOM records): (download) 
    >1pzlA (A:)
laslpsinallqaevlsrqitngdirakkiasiadvcesmkeqllvlvewakyipafcel
plddqvallrahagehlllgatkrsmvfkdvlllgndyivprhcpelaemsrvsirilde
lvlpfqelqiddneyaylkaiiffdpdakglsdpgkikrlrsqvqvsledyindrqydsr
grfgelllllptlqsitwqmieqiqfiklfgmakidnllqemllggs

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1pzlB (B:)
hkilhrllqegsps