PDB entry 1ph0
View 1ph0 on RCSB PDB site
Description: Non-carboxylic Acid-Containing Inhibitor of PTP1B Targeting the Second Phosphotyrosine Site
Class: hydrolase
Keywords: Protein Tyrosine Phosphatase 1B, oxalyl-aryl-benzoic acid compound inhibitor, salicylic acid moiety at the second site, HYDROLASE
Deposited on
2003-05-29, released
2003-07-29
The last revision prior to the SCOPe 2.06 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.213
AEROSPACI score: 0.38
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: protein-tyrosine phosphatase, non-receptor type 1
Species: Homo sapiens [TaxId:9606]
Gene: PTPN1 OR PTP1B
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d1ph0a_ - Heterogens: 418, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1ph0A (A:)
memekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsriklh
qedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmekgslk
caqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhyttwp
dfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmdkrkd
pssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkelshedle
pppehipppprppkrilephn
Sequence, based on observed residues (ATOM records): (download)
>1ph0A (A:)
emekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsriklhq
edndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmekgslkc
aqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhyttwpd
fgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmdkrkdp
ssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgd