PDB entry 1o25

View 1o25 on RCSB PDB site
Description: Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with dUMP at 2.4 A resolution
Class: transferase
Keywords: TM0449, THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN, STRUCTURAL GENOMICS, JCSG, Joint Center for Structural Genomics, PSI, Protein Structure Initiative, TRANSFERASE
Deposited on 2003-02-20, released 2003-06-24
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.199
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:2336]
    Gene: TM0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • leader sequence (10-11)
    Domains in SCOPe 2.04: d1o25a_
  • Chain 'B':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:2336]
    Gene: TM0449
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1o25b_
  • Chain 'C':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:2336]
    Gene: TM0449
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1o25c_
  • Chain 'D':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:2336]
    Gene: TM0449
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1o25d_
  • Heterogens: UMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1o25A (A:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >1o25A (A:)
hhmkidildkgfvelvdvmgndlsavraarvsfdmdeerdrhlieylmkhghetpfehiv
ftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperlegykttippervtek
iseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlradshaqw
eiqqyalaiarifkekcpwtfeaflkyaykgdil

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1o25B (B:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >1o25B (B:)
mkidildkgfvelvdvmgndlsavraarvsfdmdeerdrhlieylmkhghetpfehivft
fhvkapifvarqwfrhriasynelsgrysklsyefyipsperlegykttippervtekis
eivdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlradshaqwei
qqyalaiarifkekcpwtfeaflkyaykgdilkevqv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1o25C (C:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >1o25C (C:)
mkidildkgfvelvdvmgndlsavraarvsfdkdeerdrhlieylmkhghetpfehivft
fhvkapifvarqwfrhriasynelsgrysklsyefyipsperlegykttippervtekis
eivdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlradshaqwei
qqyalaiarifkekcpwtfeaflkyaykgdilkevqv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1o25D (D:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >1o25D (D:)
mkidildkgfvelvdvmgndlsavraarvsfdeerdrhlieylmkhghetpfehivftfh
vkapifvarqwfrhriasynelsgrysklsyefyipsperlegykttippervtekisei
vdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlradshaqweiqq
yalaiarifkekcpwtfeaflkyaykgdilkev