PDB entry 1nsg

View 1nsg on RCSB PDB site
Description: the structure of the immunophilin-immunosuppressant fkbp12-rapamycin complex interacting with human frap
Class: complex (isomerase/kinase)
Keywords: complex (isomerase/kinase), transferase, fkbp12, frap, rapamycin
Deposited on 1997-07-01, released 1998-03-18
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.196
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: fk506-binding protein
  Species: Homo sapiens [TaxId:9606]
  Gene: HUMAN HIPPOCAMPAL CDNA LIBRARY
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62942 (0-106)
  Domains in SCOPe 2.02: d1nsga_
• Chain 'B':
  Compound: fkbp-rapamycin associated protein (frap)
  Species: Homo sapiens [TaxId:9606]
  Gene: HUMAN HIPPOCAMPAL CDNA LIBRARY
  Database cross-references and differences (RAF-indexed):
  • Uniprot P42345 (0-93)
  Domains in SCOPe 2.02: d1nsgb_
• Heterogens: RAD, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1nsgA (A:)
  gvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevirgwe
  egvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1nsgB (B:)
  vailwhemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdl
  meaqewcrkymksgnvkdltqawdlyyhvfrris