PDB entry 1mdw

View 1mdw on RCSB PDB site
Description: Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation
Class: hydrolase
Keywords: Calpain Cysteine Protease Fold, Two Cooperative Calcium Sites, Helix Instability, Tryptophan-Based Active Site Blockage, HYDROLASE
Deposited on 2002-08-07, released 2003-04-29
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.207
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Calpain II, catalytic subunit
    Species: Rattus norvegicus [TaxId:10116]
    Gene: CALPAIN II
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07009
      • engineered (86)
    Domains in SCOPe 2.04: d1mdwa_
  • Chain 'B':
    Compound: Calpain II, catalytic subunit
    Species: Rattus norvegicus [TaxId:10116]
    Gene: CALPAIN II
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07009
      • engineered (86)
    Domains in SCOPe 2.04: d1mdwb_
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1mdwA (A:)
gsheraikylnqdyetlrnecleagalfqdpsfpalpsslgfkelgpyssktrgiewkrp
teicadpqfiiggatrtdicqgalgdswllaaiasltlneeilarvvpldqsfqenyagi
fhfqfwqygewvevvvddrlptkdgellfvhsaegsefwsallekayakingcyealsgg
attegfedftggiaewyelrkpppnlfkiiqkalekgsllgcsiditsaadseavtyqkl
vkghaysvtgaeevessgslqklirirnpwgqvewtgkwndncpswntvdpevranlter
qedgefwmsfsdflrhysrleicnltpd

    Sequence, based on observed residues (ATOM records): (download) 
    >1mdwA (A:)
eraikylnqdyetlrnecleagalfqdpsfpalpsslgfkelgpyssktrgiewkrptei
cadpqfiiggatrtdicqgalgdswllaaiasltlneeilarvvpldqsfqenyagifhf
qfwqygewvevvvddrlptkdgellfvhsaegsefwsallekayakingcyealsgegfe
dftggiaewyelrkpppnlfkiiqkalekgsllgcsiditsaadseavtyqklvkghays
vtgaeevessgslqklirirnpwgqvewtgkwndncpswntvdpevranlterqedgefw
msfsdflrhysrleicnlt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1mdwB (B:)
gsheraikylnqdyetlrnecleagalfqdpsfpalpsslgfkelgpyssktrgiewkrp
teicadpqfiiggatrtdicqgalgdswllaaiasltlneeilarvvpldqsfqenyagi
fhfqfwqygewvevvvddrlptkdgellfvhsaegsefwsallekayakingcyealsgg
attegfedftggiaewyelrkpppnlfkiiqkalekgsllgcsiditsaadseavtyqkl
vkghaysvtgaeevessgslqklirirnpwgqvewtgkwndncpswntvdpevranlter
qedgefwmsfsdflrhysrleicnltpd

    Sequence, based on observed residues (ATOM records): (download) 
    >1mdwB (B:)
raikylnqdyetlrnecleagalfqdpsfpalpsslgfkelgpyssktrgiewkrpteic
adpqfiiggatrtdicqgalgdswllaaiasltlneeilarvvpldqsfqenyagifhfq
fwqygewvevvvddrlptkdgellfvhsaegsefwsallekayakingcyealsegfedf
tggiaewyelrkpppnlfkiiqkalekgsllgcsiditsaadseavtyqklvkghaysvt
gaeevessgslqklirirnpwgqvewtgkwndncpswntvdpevranlterqedgefwms
fsdflrhysrleicnltp