PDB entry 1liy

View 1liy on RCSB PDB site
Description: Human erythrocyte pyruvate kinase: Arg479His mutant
Class: transferase
Keywords: nonspherocytic hemolytic anemia, erythrocyte
Deposited on 2002-04-18, released 2002-09-11
The last revision prior to the SCOP 1.73 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.74 Å
R-factor: 0.244
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (432)
    Domains in SCOP 1.73: d1liya1, d1liya2, d1liya3
  • Chain 'B':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (432)
    Domains in SCOP 1.73: d1liyb1, d1liyb2, d1liyb3
  • Chain 'C':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (432)
    Domains in SCOP 1.73: d1liyc1, d1liyc2, d1liyc3
  • Chain 'D':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (432)
    Domains in SCOP 1.73: d1liyd1, d1liyd2, d1liyd3
  • Heterogens: FBP, PGA, K, MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1liyA (A:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >1liyA (A:)
amadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniarlnfshgs
heyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpesevelvkgsqv
lvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqeglvtqvenggvlg
srkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavraalgpeghg
ikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigrcnlagkpv
vcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavkmqhaiare
aeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttghsaqllsry
rpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgiesgklrgflr
vgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1liyB (B:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >1liyB (B:)
qqqqlpadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniarlnf
shgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtivelvkgsqvlvtan
tvwvdypnivrvvpvggriyiddglislvvvenggvlgsrkgvnlpgaqdlpglseqdvr
dlrfgvehgvdivfasfvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevs
dgimvargdlgieipaekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsd
vanavldgadcimlsgetakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrd
ptevtaigaveaafkccaaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcr
gvfpllyreppeaiwaddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrv
lsi

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1liyC (C:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >1liyC (C:)
qqqlpaadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniarlnf
shgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpesevelvk
gsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpeglvtq
venggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavra
algpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigr
cnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavk
mqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttgh
saqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgies
gklrgflrvgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1liyD (D:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >1liyD (D:)
paatflehlcllidsepvaarstsiiatigpasrsverlkemikagmniarlnfshgshe
yhaesianvreavesfagsplsyrpvaialdtkgpeirtgilesevelvkgsqlvtvdpa
frtrgnantvwvdypnivrvvpvggriyiddglislvvqkipelvtqvenggvlgsrkgv
nlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavraalgpeghgikiis
kienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigrcnlagkpvvcatq
mlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavkmqhaiareaeaav
yhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttghsaqllsryrpraa
viavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgiesgklrgflrvgdlv
ivvtgwrpgsgytnimrvlsi