PDB entry 1kli

View 1kli on RCSB PDB site
Description: Cofactor-and substrate-assisted activation of factor VIIa
Class: hydrolase
Keywords: extrinsic coagulation pathway, serine protease activation, rational drug design, substrate-assisted catalysis, HYDROLASE
Deposited on 2001-12-12, released 2002-09-18
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: 0.209
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: factor VIIa
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1klih_
  • Chain 'L':
    Compound: factor VIIa
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1klil_
  • Heterogens: SO4, CA, BEN, GOL, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1kliH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1kliL (L:)
hkddqlicvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilek
rnaskpqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >1kliL (L:)
hkddqlicvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilek
r