PDB entry 1k5g

View 1k5g on RCSB PDB site
Description: Crystal structure of Ran-GDP-AlFx-RanBP1-RanGAP complex
Class: signaling protein/signaling activator
Keywords: ran, ranbp1, rangap, gap, signal transduction, nuclear transport, GTP hydrolysis, activation state, complex (GTP-binding/gtpase activation), signaling protein/signaling activator complex
Deposited on 2001-10-10, released 2002-02-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.25
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1k5ga_
  • Chain 'B':
    Compound: Ran-specific GTPase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1k5gb_
  • Chain 'C':
    Compound: Ran GTPase activating protein 1
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41391
      • see remark 999 (1)
    Domains in SCOPe 2.07: d1k5gc_
  • Chain 'D':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1k5gd_
  • Chain 'E':
    Compound: Ran-specific GTPase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1k5ge_
  • Chain 'F':
    Compound: Ran GTPase activating protein 1
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41391
      • see remark 999 (1)
    Domains in SCOPe 2.07: d1k5gf_
  • Chain 'G':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1k5gg_
  • Chain 'H':
    Compound: Ran-specific GTPase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1k5gh_
  • Chain 'I':
    Compound: Ran GTPase activating protein 1
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41391
      • see remark 999 (1)
    Domains in SCOPe 2.07: d1k5gi_
  • Chain 'J':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1k5gj_
  • Chain 'K':
    Compound: Ran-specific GTPase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1k5gk_
  • Chain 'L':
    Compound: Ran GTPase activating protein 1
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41391
      • see remark 999 (1)
    Domains in SCOPe 2.07: d1k5gl_
  • Heterogens: MG, GDP, AF3

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1k5gA (A:)
maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
alappevvmdpalaaqyehdlevaqttalpdedddl

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gA (A:)
qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
vmdpalaaqyehdlevaqttalpded

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1k5gB (B:)
maaakdthedhdtstentdesnhdpqfepivslpeqeiktleedeeelfkmraklfrfas
endlpewkergtgdvkllkhkekgairllmrrdktlkicanhyitpmmelkpnagsdraw
vwnthadfadecpkpellairflnaenaqkfktkfeecrkeieerekkagsgkndhaekv
aeklealsvkeetkedaeekq

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gB (B:)
nhdpqfepivslpeqeiktleedeeelfkmraklfrfasendlpewkergtgdvkllkhk
ekgairllmrrdktlkicanhyitpmmelkpnagsdrawvwnthadfadecpkpellair
flnaenaqkfktkfeecrkeieerek

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1k5gC (C:)
marfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskk
dleiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflsk
htplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewa
ktfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaial
kswpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvide
kmpdllflelngnrfseeddvvdeirevfstrgrgeldelddmeeltdeeeedeeeeaes
qspepetseeekedkeladelskahi

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gC (C:)
arfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskkd
leiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflskh
tplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewak
tfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaialk
swpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvidek
mpdllflelngnrfseeddvvdeirevfstrgrgeldelddmee

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1k5gD (D:)
maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
alappevvmdpalaaqyehdlevaqttalpdedddl

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gD (D:)
qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
vmdpalaaqyehdlevaqttalpded

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1k5gE (E:)
maaakdthedhdtstentdesnhdpqfepivslpeqeiktleedeeelfkmraklfrfas
endlpewkergtgdvkllkhkekgairllmrrdktlkicanhyitpmmelkpnagsdraw
vwnthadfadecpkpellairflnaenaqkfktkfeecrkeieerekkagsgkndhaekv
aeklealsvkeetkedaeekq

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gE (E:)
nhdpqfepivslpeqeiktleedeeelfkmraklfrfasendlpewkergtgdvkllkhk
ekgairllmrrdktlkicanhyitpmmelkpnagsdrawvwnthadfadecpkpellair
flnaenaqkfktkfeecrkeieerek

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1k5gF (F:)
marfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskk
dleiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflsk
htplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewa
ktfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaial
kswpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvide
kmpdllflelngnrfseeddvvdeirevfstrgrgeldelddmeeltdeeeedeeeeaes
qspepetseeekedkeladelskahi

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gF (F:)
arfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskkd
leiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflskh
tplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewak
tfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaialk
swpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvidek
mpdllflelngnrfseeddvvdeirevfstrgrgeldelddmee

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1k5gG (G:)
maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
alappevvmdpalaaqyehdlevaqttalpdedddl

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gG (G:)
qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
vmdpalaaqyehdlevaqttalpded

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1k5gH (H:)
maaakdthedhdtstentdesnhdpqfepivslpeqeiktleedeeelfkmraklfrfas
endlpewkergtgdvkllkhkekgairllmrrdktlkicanhyitpmmelkpnagsdraw
vwnthadfadecpkpellairflnaenaqkfktkfeecrkeieerekkagsgkndhaekv
aeklealsvkeetkedaeekq

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gH (H:)
nhdpqfepivslpeqeiktleedeeelfkmraklfrfasendlpewkergtgdvkllkhk
ekgairllmrrdktlkicanhyitpmmelkpnagsdrawvwnthadfadecpkpellair
flnaenaqkfktkfeecrkeieerek

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >1k5gI (I:)
marfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskk
dleiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflsk
htplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewa
ktfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaial
kswpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvide
kmpdllflelngnrfseeddvvdeirevfstrgrgeldelddmeeltdeeeedeeeeaes
qspepetseeekedkeladelskahi

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gI (I:)
arfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskkd
leiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflskh
tplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewak
tfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaialk
swpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvidek
mpdllflelngnrfseeddvvdeirevfstrgrgeldelddmee

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >1k5gJ (J:)
maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
alappevvmdpalaaqyehdlevaqttalpdedddl

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gJ (J:)
qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
vmdpalaaqyehdlevaqttalpded

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1k5gK (K:)
maaakdthedhdtstentdesnhdpqfepivslpeqeiktleedeeelfkmraklfrfas
endlpewkergtgdvkllkhkekgairllmrrdktlkicanhyitpmmelkpnagsdraw
vwnthadfadecpkpellairflnaenaqkfktkfeecrkeieerekkagsgkndhaekv
aeklealsvkeetkedaeekq

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gK (K:)
nhdpqfepivslpeqeiktleedeeelfkmraklfrfasendlpewkergtgdvkllkhk
ekgairllmrrdktlkicanhyitpmmelkpnagsdrawvwnthadfadecpkpellair
flnaenaqkfktkfeecrkeieerek

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1k5gL (L:)
marfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskk
dleiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflsk
htplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewa
ktfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaial
kswpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvide
kmpdllflelngnrfseeddvvdeirevfstrgrgeldelddmeeltdeeeedeeeeaes
qspepetseeekedkeladelskahi

    Sequence, based on observed residues (ATOM records): (download) 
    >1k5gL (L:)
arfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskkd
leiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflskh
tplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewak
tfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaialk
swpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvidek
mpdllflelngnrfseeddvvdeirevfstrgrgeldelddmee