PDB entry 1ia2
View 1ia2 on RCSB PDB site
Description: Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578)
Class: oxidoreductase
Keywords: oxidoreductase, antifungal target, reductase
Deposited on
2001-03-22, released
2001-04-11
The last revision prior to the SCOPe 2.02 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.82 Å
R-factor: 0.16
AEROSPACI score: 0.53
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: dihydrofolate reductase
Species: Candida albicans [TaxId:5476]
Gene: DFR1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d1ia2a_ - Chain 'B':
Compound: dihydrofolate reductase
Species: Candida albicans [TaxId:5476]
Gene: DFR1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d1ia2b_ - Heterogens: NDP, TQ4, MES, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1ia2A (A:)
mlkpnvaiivaalkpalgigykgkmpwrlrkeiryfkdvttrttkpntrnavimgrktwe
sipqkfrplpdrlniilsrsyeneiiddniihassiesslnlvsdvervfiiggaeiyne
linnslvshlliteiehpspesiemdtflkfpleswtkqpkselqkfvgdtvleddikeg
dftynytlwtrk
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1ia2B (B:)
mlkpnvaiivaalkpalgigykgkmpwrlrkeiryfkdvttrttkpntrnavimgrktwe
sipqkfrplpdrlniilsrsyeneiiddniihassiesslnlvsdvervfiiggaeiyne
linnslvshlliteiehpspesiemdtflkfpleswtkqpkselqkfvgdtvleddikeg
dftynytlwtrk