PDB entry 1hwj

View 1hwj on RCSB PDB site
Description: complex of the catalytic portion of human hmg-coa reductase with cerivastatin
Class: oxidoreductase
Keywords: protein-inhibitor complex
Deposited on 2001-01-09, released 2001-05-11
The last revision prior to the SCOP 1.73 freeze date was dated 2001-05-11, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.26 Å
R-factor: 0.221
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hmg-coa reductase
    Species: HOMO SAPIENS
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOP 1.73: d1hwja1, d1hwja2
  • Chain 'B':
    Compound: hmg-coa reductase
    Species: HOMO SAPIENS
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOP 1.73: d1hwjb1, d1hwjb2
  • Chain 'C':
    Compound: hmg-coa reductase
    Species: HOMO SAPIENS
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOP 1.73: d1hwjc1, d1hwjc2
  • Chain 'D':
    Compound: hmg-coa reductase
    Species: HOMO SAPIENS
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOP 1.73: d1hwjd1, d1hwjd2
  • Heterogens: ADP, 116, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hwjA (A:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwjA (A:)
prpneeclqilsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqy
lpyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcr
aiglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarl
qklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdk
kpaainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggyna
haanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnl
lpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaagh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1hwjB (B:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwjB (B:)
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrn
lyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegr
gksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyi
acgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlg
vqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1hwjC (C:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwjC (C:)
prpneeclqlsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqyl
pyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcra
iglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlq
klhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkk
paainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynah
aanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnll
pqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1hwjD (D:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwjD (D:)
lsdaeiiqlvnaletliethergvsirrqllskklsepsslqylpyrdynyslvmgacce
nvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladgm
trgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfq
srsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvc
eavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqda
aqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgack
dnpgenarqlarivcgtvmagelslmaalaag