PDB entry 1gc8

View 1gc8 on RCSB PDB site
Description: the crystal structure of thermus thermophilus 3-isopropylmalate dehydrogenase mutated at 172th from ala to phe
Class: oxidoreductase
Keywords: IPMDH, IMDH, Thermostability, dehydrogenation, decarboxylation, OXIDOREDUCTASE
Deposited on 2000-07-27, released 2000-09-27
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.17
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Thermus thermophilus [TaxId:300852]
    Gene: LEUB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5SIY4
      • see remark 999 (84)
      • engineered (171)
    Domains in SCOPe 2.02: d1gc8a_
  • Chain 'B':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Thermus thermophilus [TaxId:300852]
    Gene: LEUB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5SIY4 (0-344)
      • see remark 999 (84)
      • engineered (171)
    Domains in SCOPe 2.02: d1gc8b_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1gc8A (A:)
mkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrkg
veeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplke
eiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafefarkrrkhv
vsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnifg
dilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammleh
afglvelarkvedavakalletpppdlggsagteaftatvlrhla

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1gc8B (B:)
mkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrkg
veeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplke
eiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafefarkrrkhv
vsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnifg
dilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammleh
afglvelarkvedavakalletpppdlggsagteaftatvlrhla