PDB entry 1fdw

View 1fdw on RCSB PDB site
Description: human 17-beta-hydroxysteroid-dehydrogenase type 1 mutant h221q complexed with estradiol
Class: dehydrogenase
Keywords: dehydrogenase, 17-beta-hydroxysteroid, mutant, estradiol, nadp
Deposited on 1998-01-16, released 1998-05-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.178
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 17-beta-hydroxysteroid dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14061 (0-End)
      • engineered (220)
    Domains in SCOPe 2.07: d1fdwa_
  • Heterogens: EST, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1fdwA (A:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylaqskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgdvpakaeagaeaggg
rgpgaedeagrsavgdpelgdppaapq

    Sequence, based on observed residues (ATOM records): (download) 
    >1fdwA (A:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtagspeevldrtdihtfhrfyqylaqskqvfreaaqnpeevaevfltalra
pkptlryftterflpllrmrlddpsgsnyvtamhrevfg