PDB entry 1eao

View 1eao on RCSB PDB site
Description: the runx1 runt domain at 1.25a resolution: a structural switch and specifically bound chloride ions modulate DNA binding
Class: transcription/DNA
Keywords: transcription/DNA, acute myeloid leukemia, aml, runx1, runt domain, chloride binding, transcription factor, ig fold
Deposited on 2001-07-14, released 2002-09-12
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: 0.143
AEROSPACI score: 0.72 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: runt-related transcription factor 1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03347
      • engineered mutation (26)
      • engineered mutation (35)
    Domains in SCOPe 2.05: d1eaoa_
  • Chain 'B':
    Compound: runt-related transcription factor 1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03347
      • engineered mutation (26)
      • engineered mutation (35)
    Domains in SCOPe 2.05: d1eaob_
  • Heterogens: BR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1eaoA (A:)
sgdrsmvevladhpgelvrtdspnflssvlpthwrsnktlpiafkvvalgdvpdgtlvtv
magndenysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhra
ikitvdgpreprrhrqkldd

    Sequence, based on observed residues (ATOM records): (download) 
    >1eaoA (A:)
smvevladhpgelvrtdspnflssvlpthwrsnktlpiafkvvalgdvpdgtlvtvmagn
denysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhraikit
vdgp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1eaoB (B:)
sgdrsmvevladhpgelvrtdspnflssvlpthwrsnktlpiafkvvalgdvpdgtlvtv
magndenysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhra
ikitvdgpreprrhrqkldd

    Sequence, based on observed residues (ATOM records): (download) 
    >1eaoB (B:)
smvevladhpgelvrtdspnflssvlpthwrsnktlpiafkvvalgdvpdgtlvtvmagn
denysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhraikit
vdgp