PDB entry 1ean

View 1ean on RCSB PDB site
Description: the runx1 runt domain at 1.25a resolution: a structural switch and specifically bound chloride ions modulate DNA binding
Class: transcription/DNA
Keywords: transcription-DNA complex, acute myeloid leukemia, aml, runx1, runt domain, chloride binding, transcription factor, ig fold
Deposited on 2001-07-13, released 2002-09-12
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.204
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: runt-related transcription factor 1
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q03347
    • engineered mutation (26)
    • engineered mutation (35)
  Domains in SCOPe 2.06: d1eana_
• Heterogens: CL, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >1eanA (A:)
  sgdrsmvevladhpgelvrtdspnflssvlpthwrsnktlpiafkvvalgdvpdgtlvtv
  magndenysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhra
  ikitvdgpreprrhrqkldd
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >1eanA (A:)
  gelvrtdspnflssvlpthwrsnktlpiafkvvalgdvpdgtlvtvmagndenysaelrn
  ataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhraikitvdgp