PDB entry 1e7w
View 1e7w on RCSB PDB site
Description: one active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes
Class: oxidoreductase
Keywords: dihydrofolate reductase, pteridine reductase, shortchain dehydrogenase, methotrexate resistance, oxidoreductase
Deposited on
2000-09-11, released
2001-09-06
The last revision prior to the SCOPe 2.04 freeze date was dated
2009-04-21, with a file datestamp of
2009-04-17.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.196
AEROSPACI score: 0.51
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: pteridine reductase
Species: LEISHMANIA MAJOR [TaxId:5664]
Database cross-references and differences (RAF-indexed):
- PDB 1E7W
- Uniprot Q9U1F8 (Start-290)
Domains in SCOPe 2.04: d1e7wa_ - Chain 'B':
Compound: pteridine reductase
Species: LEISHMANIA MAJOR [TaxId:5664]
Database cross-references and differences (RAF-indexed):
- PDB 1E7W
- Uniprot Q9U1F8 (Start-290)
Domains in SCOPe 2.04: d1e7wb_ - Heterogens: NDP, MTX, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1e7wA (A:)
gshmtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpn
saitvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptp
llrndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysii
nmvdamtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppav
weghrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra
Sequence, based on observed residues (ATOM records): (download)
>1e7wA (A:)
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapvssapvtlftrcaelvaacythwgrcdvlvnnassfyptpllreametata
dlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgal
egltrsaalelaplqirvngvgpglsvlvddmppavweghrskvplyqrdssaaevsdvv
iflcsskakyitgtcvkvdggysltra
- Chain 'B':
Sequence, based on SEQRES records: (download)
>1e7wB (B:)
gshmtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpn
saitvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptp
llrndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysii
nmvdamtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppav
weghrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra
Sequence, based on observed residues (ATOM records): (download)
>1e7wB (B:)
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrgdreametatadlf
gsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgalegl
trsaalelaplqirvngvgpglsvlvdweghrskvplyqrdssaaevsdvviflcsskak
yitgtcvkvdggysltra